Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to Daphnia magna and Integration of the Datasets into the NanoCommons Knowledge Base
| Autor: | Aline Maria Zigiotto de Medeiros, Diego Stéfani T Martinez, Gabriela H. da Silva, Latif U. Khan, Anastasios G. Papadiamantis, Iseult Lynch |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
endocrine system
General Chemical Engineering Daphnia magna chemistry.chemical_element Protein Corona 02 engineering and technology nanoinformatics 010501 environmental sciences 01 natural sciences Daphnia Article lcsh:Chemistry Adsorption General Materials Science Bovine serum albumin nanosafety 0105 earth and related environmental sciences Cadmium biology harmonisation co-exposure fungi 021001 nanoscience & nanotechnology biology.organism_classification Acute toxicity nanoecotoxicity lcsh:QD1-999 chemistry Toxicity biology.protein 0210 nano-technology Nuclear chemistry |
| Zdroj: | Nanomaterials Nanomaterials, Vol 10, Iss 1936, p 1936 (2020) Volume 10 Issue 10 |
| ISSN: | 2079-4991 |
| Popis: | In this work, we evaluated the effect of protein corona formation on graphene oxide (GO) mixture toxicity testing (i.e., co-exposure) using the Daphnia magna model and assessing acute toxicity determined as immobilisation. Cadmium (Cd2+) and bovine serum albumin (BSA) were selected as co-pollutant and protein model system, respectively. Albumin corona formation on GO dramatically increased its colloidal stability (ca. 60%) and Cd2+ adsorption capacity (ca. 4.5 times) in reconstituted water (Daphnia medium). The acute toxicity values (48 h-EC50) observed were 0.18 mg L&minus 1 for Cd2+-only and 0.29 and 0.61 mg L&minus 1 following co-exposure of Cd2+ with GO and BSA@GO materials, respectively, at a fixed non-toxic concentration of 1.0 mg L&minus 1. After coronation of GO with BSA, a reduction in cadmium toxicity of 110 % and 238% was achieved when compared to bare GO and Cd2+-only, respectively. Integration of datasets associated with graphene-based materials, heavy metals and mixture toxicity is essential to enable re-use of the data and facilitate nanoinformatics approaches for design of safer nanomaterials for water quality monitoring and remediation technologies. Hence, all data from this work were annotated and integrated into the NanoCommons Knowledge Base, connecting the experimental data to nanoinformatics platforms under the FAIR data principles and making them interoperable with similar datasets. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|