Is nigrostriatal dopaminergic deficit necessary for Holmes tremor to develop? The DaTSCAN and IBZM SPECT study
| Autor: | Magdalena Koszewicz, Agata Gajos, Małgorzata Bieńkiewicz, Jarosław Sławek, Andrzej Bogucki, Janusz Dąbrowski, Jacek Kuśmierek, Sławomir Budrewicz |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Pyrrolidines Dopamine Striatum Neurology and Preclinical Neurological Studies - Original Article 030218 nuclear medicine & medical imaging Lesion Holmes tremor 03 medical and health sciences 0302 clinical medicine Postsynaptic potential Spect imaging Internal medicine Tremor medicine Humans Biological Psychiatry Tomography Emission-Computed Single-Photon Dopamine Plasma Membrane Transport Proteins IBZM business.industry Putamen Dopaminergic medicine.disease DaTSCAN Corpus Striatum Psychiatry and Mental health Endocrinology Neurology SPECT Benzamides Female Neurology (clinical) medicine.symptom Dopaminergic nigrostriatal system business Neuroscience 030217 neurology & neurosurgery Tropanes medicine.drug |
| Zdroj: | Journal of Neural Transmission |
| ISSN: | 1435-1463 0300-9564 |
| DOI: | 10.1007/s00702-017-1780-1 |
| Popis: | Holmes’s tremor (HT) is assumed to be the result of coexistence of nigrostriatal dopaminergic system impairment and the lesion of cerebello-thalamic pathways. It was suggested that dopaminergic deficiency is responsible for rest tremor, and lack of compensatory cerebellar function leads to spill of tremor into voluntary movements. Cases of HT with and without abnormalities of the presynaptic part of dopaminergic nigrostriatal were published and these findings raised the question of possibility of the postsynaptic lesion. Three patients with HT diagnosed according to criteria of Consensus Statement on Tremor were studied. In all of them SPECT imaging with ligands of presynaptic (I 123-FP CIT—DaTSCAN) and postsynaptic (I 123-iodobenzamide—IBZM) nigrostriatal dopaminergic neurons was performed. Indices of uptake in caudate and putamen normalized to nonspecific uptake in occipital cortex and indices of asymmetry for each whole striatum as well as for putamen and caudate separately were calculated. SPECT studies did not reveal asymmetry of DaTSCAN and IBZM binding in striatum in all studied subjects. The current clinical diagnostic criteria of HT are presumably insufficiently specific and when using them we identify patients both with and without the involvement of dopaminergic system. These two groups may represent tremor disorders of similar phenomenology but of different pathomechanism. |
| Databáze: | OpenAIRE |
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