Author Correction: Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan
| Autor: | Haoran Ning, Zhou Zhijun, Ding Yu, Min Mao, Daoxing Fu, Hong Liang, Jia Lu, Xia Zou, Yong Zhang, He Yanlin, Dongbo Zhou, Demei Dong, Li Taojing, Kun Deng, Li Cesheng, Hu Yong, Peng Yan, Tao Du, Xiaoming Yang, Rong Zhou, Lin Lianzhen, Huanhuan Guo, Jianhong Yu, Fengping Lu, Yong Xie, Xinxin Zhang, Huichuan Yang, Yue Shenglan, Xiao Wu, Zejun Wang, Lu Feng, Junzheng Wu, Kai Duan, Ya Zhang, Wang Feifei, Yang Gao |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 2019-20 coronavirus outbreak China Convalescent plasma Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Science Adaptive immunity General Physics and Astronomy Blood Donors Antibodies Viral General Biochemistry Genetics and Molecular Biology Antibodies Domain (software engineering) Cell Line Sex Factors Chlorocebus aethiops Medicine Animals Humans Longitudinal Studies Author Correction Vero Cells COVID-19 Serotherapy Multidisciplinary business.industry SARS-CoV-2 Immunization Passive COVID-19 Convalescence General Chemistry Specific igg Antimicrobial responses Virology Antibodies Neutralizing Immunity Humoral Viral infection Immunoglobulin G Spike Glycoprotein Coronavirus Receptors Virus Female business Immunologic Memory |
| Zdroj: | Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | To investigate the duration of humoral immune response in convalescent coronavirus disease 2019 (COVID-19) patients, we conduct a 12-month longitudinal study through collecting a total of 1,782 plasma samples from 869 convalescent plasma donors in Wuhan, China and test specific antibody responses. The results show that positive rate of IgG antibody against receptor-binding domain of spike protein (RBD-IgG) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the COVID-19 convalescent plasma donors exceeded 70% for 12 months post diagnosis. The level of RBD-IgG decreases with time, with the titer stabilizing at 64.3% of the initial level by the 9th month. Moreover, male plasma donors produce more RBD-IgG than female, and age of the patients positively correlates with the RBD-IgG titer. A strong positive correlation between RBD-IgG and neutralizing antibody titers is also identified. These results facilitate our understanding of SARS-CoV-2-induced immune memory to promote vaccine and therapy development. |
| Databáze: | OpenAIRE |
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