Baccharis dracunculifolia DC Hydroalcoholic Extract Improves Intestinal and Hippocampal Inflammation and Decreases Behavioral Changes of Colitis Mice

Autor: Tauani Caroline Santos França, Ana Julia Ribeiro, Luísa Natália Bolda Mariano, Ana Caroline dos Santos, Larissa Venzon, Lincon Bordignon Somensi, Ruan Kaio Silva Nunes, Camila André Cazarin, Karen Luz Okubo, Helenita Priscila Poerner, Jairo Kneupp Bastos, Márcia Maria de Souza, Luísa Mota da Silva
Rok vydání: 2022
Předmět:
Zdroj: Evidence-Based Complementary and Alternative Medicine. 2022:1-14
ISSN: 1741-4288
1741-427X
DOI: 10.1155/2022/5833840
Popis: The hydroalcoholic extract of B. dracunculifolia (HEBD) and its major compound p-coumaric acid were evaluated against the severity of intestinal inflammation and behavioral changes like depressive and anxious behavior in colitis mice. Colitis was induced in Swiss mice by oral dextran sulfate sodium (DSS) administration for five days. The mice received vehicle (10 ml/kg), HEBD (3, 30, or 300 mg/kg), or p-coumaric acid (15 mg/kg) orally, once a day for twelve days. Behavioral tests were performed on the 11th and 12th days after the beginning of the treatments. Moreover, the colon, cortex, and hippocampus were collected to analyze oxidative and inflammatory parameters. The treatment with HEBD (300 mg/Kg), but not p-coumaric acid, showed decreased disease activity index (DAI) values compared to the vehicle group and partially preserved the villi architecture and mucin levels. Furthermore, the HEBD increased the antioxidant defenses in the colon and hippocampus and reduced the myeloperoxidase activity and IL-6 levels in the colon from colitis mice. Colitis mice treated with HEBD did not show depressive-like behavior in the tail suspension test. HEBD reduced colon inflammation, while it maintains antioxidant defenses and mucin levels in this tissue. It may reduce neuropsychiatric comorbidities associated with colitis through its antioxidant effects.
Databáze: OpenAIRE
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