The G to A polymorphism at -597 of the interleukin-6 gene is extremely rare in southern Han Chinese
| Autor: | Hong Luan, Xin-Tao Deng, Jin-Guo Zheng, Min Pan, Jian-Hua Zhu, Li-Jun Ge, Hai-Yan Pan, Chu Chen, Min-Hui Jiang, Shu-Ping Gao |
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| Rok vydání: | 2011 |
| Předmět: |
China
Han chinese Interleukin 6 gene medicine.medical_treatment Immunology Essential hypertension Polymorphism Single Nucleotide Biochemistry Disease susceptibility Asian People Gene Frequency Genotype Ethnicity medicine Humans Immunology and Allergy Genetic Predisposition to Disease Interleukin 6 Molecular Biology Genetics biology Interleukin-6 Promoter Hematology medicine.disease Cytokine biology.protein |
| Zdroj: | Cytokine. 55:1-3 |
| ISSN: | 1043-4666 |
| DOI: | 10.1016/j.cyto.2011.03.006 |
| Popis: | Interleukin-6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes including essential hypertension (EH). Associations of the IL-6 promoter region polymorphisms with circulating level of IL-6 have been reported in various studies. We detected the IL-6-597G/A polymorphism in 246 EH patients and 194 healthy controls from Jiangsu area (south of China). Individuals all carried the GG wild genotype, no GA or AA genotypes were found. Our results suggest that IL-6-597G/A polymorphism is extremely rare and unlikely to be contributing significantly to disease susceptibility in southern Han Chinese. |
| Databáze: | OpenAIRE |
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