Patient-individual phenotypes of glioblastoma stem cells are conserved in culture and associate with radioresistance, brain infiltration and patient prognosis

Autor: Katrin Ganser, Franziska Eckert, Andreas Riedel, Nicolai Stransky, Frank Paulsen, Susan Noell, Marcel Krueger, Jens Schittenhelm, Stefanie Beck‐Wödl, Daniel Zips, Peter Ruth, Stephan M. Huber, Lukas Klumpp
Rok vydání: 2021
Předmět:
Zdroj: International journal of cancerREFERENCES. 150(10)
ISSN: 1097-0215
Popis: Identification of prognostic or predictive molecular markers in glioblastoma resection specimens may lead to strategies for therapy stratification and personalized treatment planning. Here, we analyzed in primary glioblastoma stem cell (pGSC) cultures the mRNA abundances of seven stem cell (MSI1, Notch1, nestin, Sox2, Oct4, FABP7 and ALDH1A3), and three radioresistance or invasion markers (CXCR4, IK
Databáze: OpenAIRE