Chest CT for detecting COVID-19: a systematic review and meta-analysis of diagnostic accuracy
| Autor: | Jiahao Peng, Fang Peng, Yangbo Xing, Chao Xu, Weiliang Tang, Buyun Xu, Yong Sun, Zhaohai Zheng |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19) Coronaviruses Pneumonia Viral Chest ct Context (language use) Diagnostic accuracy 030218 nuclear medicine & medical imaging Pneumonias Betacoronavirus 03 medical and health sciences Computed Tomography 0302 clinical medicine medicine Humans Radiology Nuclear Medicine and imaging Lung Pandemics Neuroradiology X-ray computed tomography medicine.diagnostic_test SARS-CoV-2 business.industry COVID-19 Reproducibility of Results Diagnostic test Interventional radiology General Medicine Radiology Nuclear Medicine and imaging 030220 oncology & carcinogenesis Meta-analysis Radiology Coronavirus Infections Tomography X-Ray Computed business |
| Zdroj: | European Radiology |
| ISSN: | 1432-1084 0938-7994 |
| Popis: | OBJECTIVE: The purpose of this article was to perform a systematic review and meta- analysis regarding the diagnostic test accuracy of chest CT for detecting Coronavirus Disease 2019 (COVID-19).METHODS: PubMed, EMBASE, Web of Science and CNKI were searched up to March 12, 2020. We included studies providing information regarding diagnostic test accuracy of chest CT for COVID-19 detection. The methodologic quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies–2 tool. Sensitivity and specificity were pooled.RESULTS: Ten studies (n = 2657 patients) were included. The risks of bias in all studies were moderate in general. Pooled sensitivity was 93% (95% CI: 85 - 97%), and only one study reported specificity (25%, 95% CI:22-30%). There was substantial heterogeneity according to the Cochran Q test (p < 0.01) and Higgins I2 heterogeneity index (96% for sensitivity). After dividing the studies into two groups based on the study site, we found that the sensitivity of chest CT was great in Wuhan (the most affected city by the epidemic) and the sensitivity values were very close to each other (97%, 96% and 99%, respectively). In the regions other than Wuhan, the sensitivity varied from 69% to 98%.CONCLUSION: Chest CT offers the great sensitivity for detecting COVID-19, especially in region with severe epidemic situation. However, the specificity is low. In the context of emergency disease control, chest CT provide a fast, convenient and effective method to early recognize suspicious cases and might contribute to confine epidemic. |
| Databáze: | OpenAIRE |
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