Optogenetically enhanced pituitary corticotroph cell activity post-stress onset causes rapid organizing effects on behaviour
| Autor: | Antonia H. Groneberg, Theresa Thiemann, Soojin Ryu, Ulrich Herget, Rodrigo J. De Marco |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Science General Physics and Astronomy Biology Stimulus (physiology) Optogenetics General Biochemistry Genetics and Molecular Biology Article Animals Genetically Modified 03 medical and health sciences Anterior pituitary Internal medicine medicine Zebrafish larvae Avoidance Learning Endocrine system Animals Corticotrophs Zebrafish QL Multidisciplinary General Chemistry Corticotroph Cell 030104 developmental biology Endocrinology medicine.anatomical_structure Corticotropic cell Neuroscience Locomotion Stress Psychological Hormone |
| Zdroj: | Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | The anterior pituitary is the major link between nervous and hormonal systems, which allow the brain to generate adequate and flexible behaviour. Here, we address its role in mediating behavioural adjustments that aid in coping with acutely threatening environments. For this we combine optogenetic manipulation of pituitary corticotroph cells in larval zebrafish with newly developed assays for measuring goal-directed actions in very short timescales. Our results reveal modulatory actions of corticotroph cell activity on locomotion, avoidance behaviours and stimulus responsiveness directly after the onset of stress. Altogether, the findings uncover the significance of endocrine pituitary cells for rapidly optimizing behaviour in local antagonistic environments. Behavioural adaptations in response to stress are thought to be regulated by rapid neurotransmitter action, followed by slower hormonal signalling. Here, using optogenetic approaches, the authors find corticotroph cell populations are capable of rapidly modulating avoidance behaviours immediately after the onset of stress. |
| Databáze: | OpenAIRE |
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