Complete diagnostics and clinical approach for a female patient with unusual glioblastoma: A case study
Autor: | Milada Kohoutová, Pavel Haninec, Petra Tesarova, Libor Stanek, Filip Šámal, Michal Filip, Ales Vicha, Tomáš Zima, Zdenek Musil, Milena Králíčková, Lubos Petruzelka, Drahomira Springer |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Cancer Research Pathology medicine.medical_specialty Gene mutation medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Diffuse Astrocytoma medicine neoplasms Oncogene biology business.industry Cancer Articles medicine.disease Molecular medicine nervous system diseases 030104 developmental biology Oncology 030220 oncology & carcinogenesis biology.protein Mdm2 KRAS business Glioblastoma |
Zdroj: | Molecular and Clinical Oncology. 5:161-164 |
ISSN: | 2049-9469 2049-9450 |
Popis: | The present study reports a case of a 44-year-old female patient with a large frontal lobe tumor who underwent surgery using a modern navigation system SonoWand that combines the advantages of a non-frame navigation system with intraoperative real-time ultrasound imaging. The right frontal lobe tumor consisted of two morphologically different sections. A diffuse astrocytoma grade II and a glioblastoma grade IV were identified. These tumors were relatively substantially separated. A 17 p deletion, including TP53, was detected in a diffuse astrocytoma but not in a glioblastoma. EGFR and MDM2 amplifications were detected only in a glioblastoma. Detection of these amplifications is typical for primary glioblastomas. These findings support our assumption of two independent tumors. The KRAS, BRAF and EGFR gene mutations were also detected in a glioblastoma. Such an accumulation of molecular mutations is rare in one tumor. Following oncological treatment the patient was cared for in the oncological center and survived for 15 months after the surgery without any signs of a disease. This is an unusual case, and to the best of our knowledge, is not frequently published in literature. |
Databáze: | OpenAIRE |
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