Effects of Second and Third Generation Oral Contraceptives on Lipid and Carbohydrate Metabolism in Overweight and Obese Women: A Randomized Triple-Blind Controlled Trial
| Autor: | Azizeh Farshbaf-Khalili, Samira Pourzeinali-Beilankouh, Farnaz Sadrimehr, Mahnaz Shahnazi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Population Levonorgestrel 030204 cardiovascular system & hematology Overweight 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Desogestrel Internal medicine Medicine Obesity education Glucose tolerance test education.field_of_study 030219 obstetrics & reproductive medicine medicine.diagnostic_test business.industry Cholesterol Lipid metabolism General Medicine Endocrinology chemistry Carbohydrate Metabolism medicine.symptom business Body mass index Research Article medicine.drug |
| Zdroj: | Iranian Red Crescent Medical Journal |
| ISSN: | 2074-1812 2074-1804 |
| Popis: | Background: Combined oral contraceptives (COCs) have not been shown to have major effects on lipid and carbohydrate metabolism in normal-weight women. However, we have limited information about the effects on women at high risk for cardiovascular disease and diabetes due to being overweight and obese. Objectives: To evaluate the effects of second and third generation contraceptive pills on lipid and carbohydrate metabolism in overweight and obese women. Patients and Methods: This triple-blind controlled trial was performed on 137 healthy women aged 18 - 40 years with a body mass index of 25-34.9 (kg/m2) who were referred to health centers in Tabriz, Iran from 2014 to 2015. The women were randomly divided into groups who were to take 30 mcg ethinyl estradiol/150 mcg levonorgestrel (EE/LGN) (n = 69) or 30 mcg ethinyl estradiol/150 mcg desogestrel (EE/DSG) (n = 68) with an allocation ratio of 1: 1 for three cycles. As primary outcomes, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and fasting plasma glucose (FPG) were assessed; total cholesterol (TC), triglycerides (TG), and 2-hour plasma glucose in the 75-g oral glucose tolerance test (2-hour 75-g OGTT) were assessed as secondary outcomes. Results: The differences in lipid and carbohydrate parameters were not significant between the two groups, except for HDL-C (Adjusted MD (CI95%) = 7.00 (2.98 to 11.02)). HDL-C decreased with EE/LGN (P = 0.016) and increased with EE/DSG (P = 0.004). LDL-C and TC increased in both groups, whereas TG increased only with EE/DSG (P < 0.05). Compared with the baseline, FPG levels did not differ significantly in both groups, but EE/DSG increased 2-hour 75-g OGTT (P = 0.010). Conclusions: We observed no significant differences between the two groups in lipid and carbohydrate metabolism, except for HDL-C. Considering the importance of overweight and obese women’s health, studies with longer follow-up periods are recommended in this respect. |
| Databáze: | OpenAIRE |
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