The tiny big world of solid lipid nanoparticles and nanostructured lipid carriers: an updated review

Autor:	Heidi M, Abdel-Mageed, Amira E, Abd El Aziz, Saleh A, Mohamed, Nermeen Z, AbuelEzz
Rok vydání:	2022
Předmět:	Drug Carriers Colloid and Surface Chemistry Liposomes Organic Chemistry Nanoparticles Pharmaceutical Science Bioengineering Physical and Theoretical Chemistry Lipids Nanostructures
Zdroj:	Journal of Microencapsulation. 39:72-94
ISSN:	1464-5246 0265-2048
DOI:	10.1080/02652048.2021.2021307
Popis:	Nanotechnology is currently a field of endeavour that has reached a maturation phase beyond the initial hypotheses with an undercurrent challenge to optimise the safety, and scalability for production and clinical trials. Lipid-based nanoparticles (LNP), namely solid lipid nanoparticles (SLN) and nanostructured lipid (NLC), carriers are presently among the most attractive and fast-growing areas of research. SLN and NLC are safe, biocompatible nanotechnology-enabled platforms with ubiquitous applications. This review presents a modern vision that starts with a brief description of characteristics, preparation strategies, and composition ingredients, benefits, and limitations. Next, a discussion of applications and functionalization approaches for the delivery of therapeutics via different routes of delivery. Additionally, the review presents a concise perspective into limitations and future advances. A brief recap on the prospects of molecular dynamics simulations in better understanding NP bio-interface interactions is provided. Finally, the alliance between 3D printing and nanomaterials is presented here as well.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608d5c8c7eecebeb5efa66a5b2e6b4fd https://doi.org/10.1080/02652048.2021.2021307 Zobrazit plný text záznamu Plný text ve formátu PDF