The tiny big world of solid lipid nanoparticles and nanostructured lipid carriers: an updated review
| Autor: | Heidi M, Abdel-Mageed, Amira E, Abd El Aziz, Saleh A, Mohamed, Nermeen Z, AbuelEzz |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Microencapsulation. 39:72-94 |
| ISSN: | 1464-5246 0265-2048 |
| Popis: | Nanotechnology is currently a field of endeavour that has reached a maturation phase beyond the initial hypotheses with an undercurrent challenge to optimise the safety, and scalability for production and clinical trials. Lipid-based nanoparticles (LNP), namely solid lipid nanoparticles (SLN) and nanostructured lipid (NLC), carriers are presently among the most attractive and fast-growing areas of research. SLN and NLC are safe, biocompatible nanotechnology-enabled platforms with ubiquitous applications. This review presents a modern vision that starts with a brief description of characteristics, preparation strategies, and composition ingredients, benefits, and limitations. Next, a discussion of applications and functionalization approaches for the delivery of therapeutics via different routes of delivery. Additionally, the review presents a concise perspective into limitations and future advances. A brief recap on the prospects of molecular dynamics simulations in better understanding NP bio-interface interactions is provided. Finally, the alliance between 3D printing and nanomaterials is presented here as well. |
| Databáze: | OpenAIRE |
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