Metabolomics, a New Promising Technology for Toxicological Research

Autor: Byung Mu Lee, Kyu-Bong Kim
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Zdroj: Toxicological Research
ISSN: 2234-2753
1976-8257
Popis: Metabolomics which deals with the biological metabolite profile produced in the body and its relation to disease state is a relatively recent research area for drug discovery and biological sciences including toxicology and pharmacology. Metabolomics, based on analytical method and multivariate analysis, has been considered a promising technology because of its advantage over other toxicogenomic and toxicoproteomic approaches. The application of metabolomics includes the development of biomarkers associated with the pathogenesis of various diseases, alternative toxicity tests, high-throughput screening (HTS), and risk assessment, allowing the simultaneous acquisition of multiple biochemical parameters in biological samples. The metabolic profile of urine, in particular, often shows changes in response to exposure to xenobiotics or disease-induced stress, because of the biological system’s attempt to maintain homeostasis. In this review, we focus on the most recent advances and applications of metabolomics in toxicological research.
Databáze: OpenAIRE
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