Interferon Lambda Family along with HTLV-1 Proviral Load, Tax, and HBZ Implicated in the Pathogenesis of Myelopathy/Tropical Spastic Paraparesis
| Autor: | Narges Valizadeh, Hamid Reza Jahantigh, Houshang Rafatpanah, Asadollah Mohammadi, Samira Basharkhah, Seyed Abdolrahim Rezaee, Sayed-Hamidreza Mozhgani |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Retroviridae Proteins Human T-lymphotropic virus Asymptomatic Interferon Lambda Pathogenesis Young Adult 03 medical and health sciences Myelopathy Proviruses immune system diseases Interferon Tropical spastic paraparesis medicine Humans Receptors Cytokine Inverse correlation Aged Receptors Interferon Interferon type III Human T-lymphotropic virus 1 biology business.industry Genes pX Interleukins virus diseases Middle Aged medicine.disease biology.organism_classification Paraparesis Tropical Spastic Basic-Leucine Zipper Transcription Factors 030104 developmental biology Neurology Immunology Leukocytes Mononuclear Female Interferons Neurology (clinical) medicine.symptom business medicine.drug |
| Zdroj: | Neurodegenerative Diseases. 18:150-155 |
| ISSN: | 1660-2862 1660-2854 |
| DOI: | 10.1159/000490058 |
| Popis: | HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic neuroinflammatory disease related to human T lymphotropic virus type 1 (HTLV-1) infection. Interferon type III (IFN-λ), which includes IL28, IL29, and IL28R, and affects the outcome of viral infections, might be complicated in the progression of HAM/TSP. Here, we investigated the host-virus interactions in the manifestation of HAM/TSP, using IL28B, IL29, IL28R, HTLV-1 Tax, HTLV-1 basic leucine zipper factor (HBZ), and proviral load (PVL). The study groups consisted of 20 patients with HAM/TSP, 20 asymptomatic HTLV-1 carriers (ACs), and 20 healthy controls (HCs). The means of PVL, Tax, and HBZ gene expressions in the HAM/TSP group (p = 0.004, 0.006, and < 0.0001, respectively) were significantly higher than in the AC group. The comparison of IL28B, IL29, and IL28R expression in the HAM/TSP, AC, and HC groups revealed no significant difference between the first 2, but lower concentrations in the HCs (IL28B: p = 0.03, 0.01; IL29: p = 0.07, 0.01; and IL28R: p < 0.0001, respectively). In the HAM/TSP group, correlations were seen between Tax and HBZ (R = 0.61, p = 0.004) and between Tax and IL29 (R = 0.45, p = 0.04). Negative correlations were observed between Tax and IL28B (R = –0.49, p = 0.02) and between HBZ and IL28R (R = –0.43, p = 0.06). In the ACs, an inverse correlation was found between Tax and IL28B (R = –0.42, p = 0.06). These findings suggest that IL29, IL28B, and IL28R interfere in the infection of HAM/TSP, mainly via Tax activation. |
| Databáze: | OpenAIRE |
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