Oral and intravenous glucose-induced insulin secretion in hyperthyroid patients
| Autor: | Tadasu Ikeda, Tazue Hoshino, Tatsuo Takeuchi, Hiroto Mashiba, Masato Tominaga, Katsumi Fujiyama |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Carbohydrates Administration Oral Blood sugar Hyperthyroidism Thyroid function tests Endocrinology Oral administration Internal medicine Insulin Secretion medicine Humans Insulin Pancreatic hormone Glucose tolerance test C-Peptide medicine.diagnostic_test business.industry Metabolism Glucose Tolerance Test Middle Aged Carbohydrate Glucagon Glucose Injections Intravenous Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Metabolism. 39:633-637 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/0026-0495(90)90031-7 |
| Popis: | To elucidate glucose intolerance in hyperthyroidism, insulin response to oral (75 g) and intravenous (IV) (20 g) glucose administration was investigated in 18 hyperthyroid patients and six normal control subjects. In oral glucose tolerance tests (OGTT), plasma insulin and C-peptide levels in hyperthyroid patients were not significantly different from that in controls; however, an impaired blood sugar response was observed in hyperthyroid patients. In IVGTT, blood sugar, plasma insulin, and C-peptide levels were significantly higher in hyperthyroid patients than in controls. Insulin secretion in proportion to blood sugar stimulus (the sum of increment in insulin divided by the sum of increment in blood sugar after glucose load, sigma delta IRI/sigma delta BS) in IVGTT was similar in hyperthyroid patients and controls; however, that in OGTT was significantly lower in hyperthyroid patients. After thyroid function tests had returned to normal by treatment with thiamazole, glucose tolerance and sigma delta IRI/sigma delta BS in OGTT were almost normalized. These results indicate that decreased insulin secretion after oral glucose may have an important role in abnormal oral glucose metabolism in hyperthyroidism. |
| Databáze: | OpenAIRE |
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