Beneficial immunomodulatory and neuro digestive effect in Trypanosoma cruzi infection after Lycopodium clavatum 13c treatment
| Autor: | Paula Fernanda Massini, Fabiana Nabarro Ferraz, Gislaine Janaina Falkowski Temporini, Carina Ribeiro Lopes, Camila Fernanda Brustolin Aleixo, Silvana Marques de Araújo, Denise Lessa Aleixo |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Chagas disease Male Lycopodium clavatum Colon medicine.medical_treatment Trypanosoma cruzi Microbiology Lycopodium Immunomodulation 03 medical and health sciences Interferon-gamma 0302 clinical medicine Immune system medicine Animals Interferon gamma Chagas Disease Rats Wistar Neurons biology Plant Extracts Homeopathy biology.organism_classification medicine.disease Interleukin-12 030205 complementary & alternative medicine Interleukin-10 Rats Interleukin 10 Disease Models Animal 030104 developmental biology Infectious Diseases Cytokine Cell Body Immunology Interleukin 12 Cytokines Digestion Interleukin-4 medicine.drug |
| Zdroj: | Microbial pathogenesis. 112 |
| ISSN: | 1096-1208 |
| Popis: | Studies show that highly diluted medications demonstrate benefits in treating infections, constituting an alternative for their treatment. The present study evaluated the effects of Lycopodium clavatum, dynamization 13c, in Wistar rats infected with T. cruzi. In this study 42 male rats were intraperitoneally inoculated with T. cruzi - Y strain and allocated into groups: IC (infected control group) and Ly (treated with L. clavatum 13c). The cytokines dosage (IFN-γ, IL-12, IL-10, IL-4), quantification and morphometry of myenteric neurons were evaluated. The treatment with L. clavatum modifies the immune response, with increase of IFN-γ on day 10 a.i. and IL-12 on day 24 a.i., decrease of IL-10 concentration on day 10 a.i. and subsequent increase of this cytokine and IL-4 on day 24 a.i., affording a bigger number of myenteric neurons compared to IC group. Thus, L. clavatum 13c promoted on rats infected with T. cruzi a beneficial immunomodulatory action reducing the pathogenic progression of digestive Chagas disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect