Serum thyroxine and age — rather than thyroid volume and serum TSH — are determinants of the thyroid radioiodine uptake in patients with nodular goiter
| Autor: | Viveque Egsgaard Nielsen, Henrik Boel-Jørgensen, Steen Joop Bonnema, Laszlo Hegedüs, Peter Grupe, Peter B. Andersen, Søren Fast |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Aging endocrine system medicine.medical_specialty Goiter endocrine system diseases Radioiodine uptake Endocrinology Diabetes and Metabolism Thyroid Gland Thyrotropin chemistry.chemical_element Thyroid Function Tests Iodine Thyroid function tests Gastroenterology Iodine Radioisotopes Young Adult Endocrinology Internal medicine medicine Humans In patient Prospective Studies Young adult Prospective cohort study Aged Aged 80 and over medicine.diagnostic_test business.industry Thyroid Middle Aged medicine.disease Thyroxine medicine.anatomical_structure chemistry Female business Goiter Nodular |
| Zdroj: | Journal of Endocrinological Investigation. 34:e52-e57 |
| ISSN: | 1720-8386 0391-4097 |
| DOI: | 10.1007/bf03347076 |
| Popis: | Background: Radioiodine (131|) therapy is widely used for treatment of non-toxic goiters. A limitation for this treatment is a low thyroid radioiodine uptake (RAIU), often encountered in these patients. Aim: To estimate the impact of various factors on the thyroid RAIU. Methods: We examined prospectively 170 patients (146 females; age range: 22–87 yrs) with nodular goiter (median 64 ml, range: 20–464 ml) selected for 131| therapy. Serum TSH was sub-normal in 42.4%. None were treated with anti-thyroid drugs. The thyroid RAIU was determined at 24h and 96h. The goiter volume was measured by ultrasound (no.=127), or by magnetic resonance imaging (no.=43). Results: The 24h and the 96h RAIU were 34.2±9.8(SD)% (range: 11.4–66.0%) and 34.0±10.0% (range: 10.5–60.9%), respectively. Sixty-one patients had a 24h RAIU |
| Databáze: | OpenAIRE |
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