Brain damage following low flow cardiopulmonary bypass in pigs
| Autor: | Ulrich L.S. Andersen, Henning Laursen, Jens Friis Lund, Hans Rahbek Sørensen, J. Waaben, Albert Gjedde, K. Gefke, Søren Aggestrup |
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| Rok vydání: | 1994 |
| Předmět: |
Pulmonary and Respiratory Medicine
Swine Cerebral glucose metabolism Brain Edema Brain damage Brain Ischemia law.invention Capillary Permeability Central nervous system disease law Cardiopulmonary bypass Animals Medicine Cerebral dysfunction Cardiopulmonary Bypass business.industry Brain General Medicine Carbon Dioxide medicine.disease Oxygen Pump flow Blood-Brain Barrier Regional Blood Flow Astrocytes Anesthesia Nerve Degeneration Brain Damage Chronic Surgery medicine.symptom Cardiology and Cardiovascular Medicine business Complication Perfusion Blood Flow Velocity |
| Zdroj: | Waaben, J, Sørensen, H R, Andersen, U L, Gefke, K, Lund, J, Aggestrup, S, Laursen, H & Gjedde, A 1994, ' Brain damage following low flow cardiopulmonary bypass in pigs. ', European Journal of Cardio-Thoracic Surgery, vol. 8, no. 2, pp. 91-6 . Scopus-Elsevier University of Southern Denmark |
| ISSN: | 1010-7940 |
| DOI: | 10.1016/1010-7940(94)90099-x |
| Popis: | Udgivelsesdato: 1994-null Reduction of pump flow during cardiopulmonary bypass (CPB) reduces the formation of microemboli and trauma to the blood components, reduces both rewarming of the heart and the noncoronary collateral flow, and improves surgical exposure. Recent studies indicate that a reduction in pump flow, even at normothermia, does not increase the incidence of postoperative cerebral dysfunction. We examined the cerebral consequences of 2 h of normothermic CPB in pigs carried out at pump flows of either 70 ml/kg per min or 50 ml/kg per min, and compared the results with those of a nonperfused control group. We measured the regional cerebral glucose metabolism and the regional capillary diffusion capacity simultaneously in ten different brain regions. Brain morphology, the blood-brain barrier permeability to serum proteins and the regional cerebral water content were also determined in the same animals. Glucose metabolism decreased significantly in both CPB groups (P < 0.001), and significant differences were found between the capillary diffusion capacities of the three groups (P < 0.05), with decreases in eight out of ten brain regions examined in the 50 ml/kg per min group. The results indicate that a reduction of pump flows from 70 ml/kg per min to 50 ml/kg per min is deleterious to the brain, and that a pump flow of 70 ml/kg per min itself has an injurious effect, when normothermic CPB is carried out for 2 h without the use of vasoactive drugs to maintain the blood pressure. Mean arterial blood pressure (MAP) rather than pump flow seemed to determine the adequacy of the cerebral perfusion. |
| Databáze: | OpenAIRE |
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