A Comparison Between Radioimmunotherapy and Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Peritoneal Carcinomatosis of Colonic Origin in Rats

Autor: O.C. Boerman, Thijs Hendriks, Robert P. Bleichrodt, Wim J.G. Oyen, Frits Aarts, Manuel J. Koppe
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Oncology
medicine.medical_specialty
Colorectal cancer
medicine.medical_treatment
Mitomycin
Heated intraperitoneal chemotherapy
Aetiology
screening and detection [ONCOL 5]
Lutetium
Gastroenterology
Peritoneal Neoplasm
Immune Regulation [NCMLS 2]
Translational research [ONCOL 3]
Surgical oncology
Internal medicine
medicine
Combined Modality Therapy
Animals
Cytoreductive surgery
Infusions
Parenteral
Survival rate
Adjuvant
Peritoneal Neoplasms
Antibiotics
Antineoplastic
Gastrointestinal Oncology
business.industry
Body Weight
Antibodies
Monoclonal
Immunotherapy
gene therapy and transplantation [UMCN 1.4]
Rats
Inbred Strains
Hyperthermia
Induced
Neoplasms
Experimental
Radioimmunotherapy
medicine.disease
Colon cancer
Rats
Pathogenesis and modulation of inflammation [N4i 1]
Survival Rate
Disease Models
Animal
Treatment Outcome
Evaluation of complex medical interventions [NCEBP 2]
Colonic Neoplasms
Surgery
Hyperthermic intraperitoneal chemotherapy
business
Peritoneal carcinomatosis
Zdroj: Annals of Surgical Oncology
Annals of Surgical Oncology, 14, 3274-82
Annals of Surgical Oncology, 14, 11, pp. 3274-82
ISSN: 1534-4681
1068-9265
Popis: Contains fulltext : 52894.pdf (Publisher’s version ) (Closed access) BACKGROUND: Cytoreductive surgery (CS) followed by heated intraperitoneal chemotherapy (HIPEC) is considered the standard of care for the treatment of patients with peritoneal carcinomatosis (PC) of colorectal cancer (CRC). These surgical procedures result in a median survival of 2 years at the cost of considerable morbidity and mortality. In preclinical studies, radioimmunotherapy (RIT) improved survival after CS in a model of induced PC of colonic origin. In the present studies we aimed to compare the efficacy and toxicity of CS followed by adjuvant RIT in experimental PC to the standard of care, HIPEC. METHODS: PC was induced by intraperitoneal inoculation of CC-531 colon carcinoma cells in three groups of Wag/Rij rats. Treatment comprised CS only, CS + RIT or CS + HIPEC, immediately after surgery. RIT consisted of intraperitoneal administration of 74 MBq Lutetium-177 labeled MG1. HIPEC was performed by a closed abdomen perfusion technique using mitomycin C (16 mg/L during 60 minutes). The primary endpoint was survival. RESULTS: CS only or combined with RIT was well tolerated. Rats receiving CS + HIPEC were lethargic, suffered from diarrhea, and lost significantly more weight in the first postoperative week. Median survival of rats treated with CS + RIT was significantly longer than after CS alone (97 and 57 days, respectively, P < .004), whereas survival after CS + HIPEC or CS alone were not significantly different (76 and 57 days, respectively, P = .17). CONCLUSION: Survival after CS was significantly improved by RIT with Lutetium-177-MG1 in rats with PC of colorectal origin. Adjuvant HIPEC did not improve survival and was more toxic than adjuvant RIT.
Databáze: OpenAIRE
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