Hypocoprins A–C: New Sesquiterpenoids from the Coprophilous Fungus Hypocopra rostrata
| Autor: | Qun Yue, Gerald F. Bills, James B. Gloer, Dinith R. Jayanetti |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Staphylococcus aureus
Antifungal Agents Stereochemistry Pharmaceutical Science Fungus Biology Article Analytical Chemistry Cyclopropane chemistry.chemical_compound Fungal metabolite Genus Drug Discovery Botany Animals Horses Xylariales Nuclear Magnetic Resonance Biomolecular Pharmacology Molecular Structure Strain (chemistry) Organic Chemistry biology.organism_classification Texas Manure Complementary and alternative medicine chemistry Molecular Medicine Fusidic Acid Sesquiterpenes Two-dimensional nuclear magnetic resonance spectroscopy Hypocopra rostrata |
| Zdroj: | Journal of Natural Products |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np5007718 |
| Popis: | Studies of the coprophilous fungus Hypocopra rostrata (TTI-0009, NRRL 66178) isolated from a sample of horse dung collected in Texas led to the isolation of three new sesquiterpenoids that we named hypocoprins A–C (1–3), together with the known fungal metabolite helvolic acid. The new metabolites have a distinctive ring system consisting of fused cyclopropane and cyclodecene units not previously reported from a fungal source. Compounds 1 and 3 moderately inhibited growth of Staphylococcus aureus. The structures of these metabolites were assigned mainly by analysis of 2D NMR and HRESITOFMS data. Relative and absolute configurations were assigned by interpretation of NMR J-values and NOESY data and by application of Mosher’s method. These results represent the first report of chemistry from any strain of the genus Hypocopra. |
| Databáze: | OpenAIRE |
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