Treatment of chronic discoid lupus erythematosus with quinacrine
| Autor: | James R. Driver, Paul V. Chivington, Shaker Heights, Harold N. Cole |
|---|---|
| Rok vydání: | 1953 |
| Předmět: |
medicine.medical_specialty
Lupus erythematosus business.industry General Medicine medicine.disease Dermatology Surgery Lupus Erythematosus Discoid Quinacrine Medicine Lupus Erythematosus Systemic High incidence skin and connective tissue diseases business Chronic discoid lupus erythematosus Quinacrine Hydrochloride PSYCHIC DISTURBANCE |
| Zdroj: | Journal of the American Medical Association. 153(17) |
| ISSN: | 0002-9955 |
| Popis: | The article by Page 1 on the treatment of 18 patients with lupus erythematosus with quinacrine hydrochloride (Atabrine) has initiated widespread interest in the United States regarding this subject. As early as 1940, Prokoptchouk 2 reported the use of quinacrine (Acrichin) in 35 patients with lupus erythematosus and was impressed with its effectiveness. Popoff and Kutinscheff 3 observed remission of lupus erythematosus in six patients treated with quinacrine in 1941. Krynski 4 treated six patients during the period 1940-1945. Pseudoicterus developed in one patient, and another showed a temporary psychic disturbance. He concluded that the method was effective but that the high incidence of side-reactions probably made its more general usage unwarranted. It has since been shown that the American product Atabrine (quinacrine hydrochloride, U. S. P.) probably is less toxic and produces fewer side-effects than Acrichin the Russian product or its German analogue Atabrin. 5 Bispham, 6 in a |
| Databáze: | OpenAIRE |
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