Variation in the miRNA-433 binding site of FGF20 is a risk factor for Parkinson's disease in Iranian population
| Autor: | Shahram Torkamandi, Shaghayegh Taghavi, Saeed Mohammadihosseinabad, Mohammad Reza Abbaszadegan, Neda Shahmohammadibeni, Shokoufeh Abdollahi, Marzieh Motallebi, Negar Pedram, Leyla HaghNejad, Masoumeh Amini Gavenaroudi, Ehsan Ahmadi, Abolfazl Movafagh, Hamid Ghaedi, Babak Emamalizadeh, Amir Ehtesham Shafiei Zarneh, Atena Fazeli, Gholam Ali Shahidi, Hossein Darvish, Javad Jamshidi, Alireza Zare Bidoki, Abbas Tafakhori |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Parkinson's disease Genotype FGF20 Disease Iran Biology Polymorphism Single Nucleotide Gene Frequency Risk Factors Polymorphism (computer science) medicine Humans SNP Genetic Predisposition to Disease Allele Risk factor Aged Genetics Chi-Square Distribution Parkinson Disease Middle Aged medicine.disease Genotype frequency Fibroblast Growth Factors Neurology Female Neurology (clinical) |
| Zdroj: | Journal of the Neurological Sciences. 355:72-74 |
| ISSN: | 0022-510X 1272-0208 |
| DOI: | 10.1016/j.jns.2015.05.020 |
| Popis: | DNA variations in the fibroblast growth factor 20 gene have been reported to be associated with Parkinson's disease (PD). The rs12720208, a functional SNP located in the 3'UTR region of the gene, was reported as a risk factor for PD. A number of studies, which tried to replicate the result in different populations, failed to detect any associations. In this study, we genotyped rs2720208 SNP in 520 PD patients and 520 healthy controls both from Iran. Significant differences were found in allele and genotype frequencies between patients and controls (p |
| Databáze: | OpenAIRE |
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