Sialic acid surface decoration enhances cellular uptake and apoptosis-inducing activity of selenium nanoparticles
| Autor: | Wenjie Zheng, Jun Sheng Zheng, Bo Yu, Yibo Zhang, Tianfeng Chen, Shan Yuan Zheng, Fang Yang |
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| Rok vydání: | 2011 |
| Předmět: |
inorganic chemicals
Surface Properties Poly ADP ribose polymerase Cell Antineoplastic Agents Apoptosis HeLa Selenium chemistry.chemical_compound Colloid and Surface Chemistry medicine Humans Physical and Theoretical Chemistry Cytotoxicity biology Cell Cycle technology industry and agriculture Surfaces and Interfaces General Medicine Cell cycle Flow Cytometry biology.organism_classification N-Acetylneuraminic Acid Sialic acid medicine.anatomical_structure chemistry Biochemistry Biophysics Nanoparticles Drug Screening Assays Antitumor N-Acetylneuraminic acid HeLa Cells Biotechnology |
| Zdroj: | Colloids and Surfaces B: Biointerfaces. 83:183-187 |
| ISSN: | 0927-7765 |
| DOI: | 10.1016/j.colsurfb.2010.11.023 |
| Popis: | A simple method for fabrication of sialic acid surface-decorated selenium nanoparticles (SA-Se-NPs) with enhanced cancer-targeting and cell-penetrating abilities has been demonstrated in the present study. Monodisperse and homogeneous spherical SA-Se-NPs with striking stability were prepared under the optimized conditions. SA surface decoration significantly increased the cellular uptake and cytotoxicity of Se-NPs in HeLa human cervical carcinoma cells. Treatments of SA-Se-NPs induced dose-dependent apoptosis in HeLa cells, as evidenced by increase in sub-G1 cell populations, nuclear condensation and formation of apoptotic bodies. Further investigation on molecular mechanisms reveals that SA-Se-NPs triggered cancer cell apoptosis through activation of caspase-3 and subsequent cleavage of PARP. |
| Databáze: | OpenAIRE |
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