Physical Conditioning Augments the Fibrinolytic Response to Venous Occlusion in Healthy Adults
| Autor: | Logue Ee, Andrew G. Wallace, R. S. Williams, James G. Lewis, Barton T, Salvatore V. Pizzo, Stead Nw |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.medical_treatment Physical fitness Stimulation Veins Plasminogen Activators chemistry.chemical_compound Sex Factors Heart Rate Internal medicine Heart rate Fibrinolysis medicine Humans Treadmill Aged Blood Specimen Collection Physical Education and Training Physical conditioning business.industry Cholesterol Venous occlusion General Medicine Middle Aged Surgery chemistry Physical Fitness Exercise Test Cardiology Female business |
| Zdroj: | New England Journal of Medicine. 302:987-991 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm198005013021802 |
| Popis: | The effects of a 10-week physical-conditioning program on fibrinolytic activity at rest and after stimulation by venous occlusion were studied in 69 healthy adults 25 to 69 years old. Physical conditioning was documented by treadmill performance, and fibrinolysis was measured with a newly developed radioenzymatic assay. Whereas fibrinolysis declined at rest from 16.2 +/- 1.3 to 11.4 +/- 0.8 units (mean +/- S.E.M.) (P = 0.0017), the increment in fibrinolysis produced by venous occlusion was increased from 21.7 +/- 2.9 to 33.8 +/- 4.7 units (P = 0.0037). This augmentation was most marked in women, persons with low initial levels of stimulated fibrinolysis, and persons with low initial physical fitness. We conclude that physical conditioning can enhance the augmentation of fibrinolytic activity that occurs in response to venous occlusion. Enhanced fibrinolysis in response to thrombotic stimuli could be an important mechanism in the beneficial effect of habitual physical activity on the risk of cardiovascular disease. |
| Databáze: | OpenAIRE |
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