Endothelial progenitor cells for cancer gene therapy
| Autor: | Beltinger C, J. Wei, Klaus-Michael Debatin |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Programmed cell death
Genetic enhancement Apoptosis Gene delivery Biology Virus Cell Movement Neoplasms Genetics medicine Animals Humans Progenitor cell Molecular Biology Neovascularization Pathologic Endothelial Cells Cancer Genetic Therapy medicine.disease Endothelial stem cell embryonic structures Immunology cardiovascular system Cancer research Molecular Medicine Genetic Engineering Stem Cell Transplantation circulatory and respiratory physiology Homing (hematopoietic) |
| Zdroj: | Gene Therapy. 15:780-786 |
| ISSN: | 1476-5462 0969-7128 |
| DOI: | 10.1038/gt.2008.36 |
| Popis: | Endothelial progenitor cells (EPCs) are promising for cancer therapy because they specifically target tumors. They have the capacity to home to, invade, migrate within and incorporate into tumor structures. They are easily expanded and can be armed with therapeutic payloads protected within the progenitor cells. Once in the tumor, armed EPCs can be triggered to induce cell death in surrounding tumor cells while being transiently protected from premature demise. In preclinical studies, therapeutic EPCs attenuated tumor growth and increased survival. Enhancing homing, self-protection and collateral tumor cell damage will increase the efficacy of EPCs for cancer gene therapy. |
| Databáze: | OpenAIRE |
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