Consequences of negative energy balance on follicular development and oocyte quality in primiparous sows†

Autor: Costermans, N G J, Teerds, K J, Middelkoop, A, Roelen, B A J, Schoevers, E J, van Tol, H T A, Laurenssen, B, Koopmanschap, R E, Zhao, Y, Blokland, M, van Tricht, F, Zak, L, Keijer, J, Kemp, B, Soede, N M, Dep Biochemie en Celbiologie, Sub Software Technology begr. 1-1-13, LS Voortplanting Inwendige Ziekten, Sub Celbiologisch lab., dES/dFAH FR, Dep Gezondheidszorg Landbouwhuisdieren, Sub Condensed Matter and Interfaces
Přispěvatelé: Dep Biochemie en Celbiologie, Sub Software Technology begr. 1-1-13, LS Voortplanting Inwendige Ziekten, Sub Celbiologisch lab., dES/dFAH FR, Dep Gezondheidszorg Landbouwhuisdieren, Sub Condensed Matter and Interfaces
Rok vydání: 2019
Předmět:
0301 basic medicine
in vitro maturation (IVM)
Litter Size
Swine
medicine.medical_treatment
BU Veterinary Drugs
Ovarian Follicle
Lactation
Follicular phase
food and beverages
04 agricultural and veterinary sciences
General Medicine
Polyspermy
Parity
medicine.anatomical_structure
Human and Animal Physiology
Adaptation Physiology
Female
Research Article
zygote
follicular development
lactation
Biology
follicle
BU Dierbehandelingsmiddelen
insulin-like growth factor
03 medical and health sciences
Follicle
Animal science
estradiol
medicine
Animals
Weaning
Adaptatiefysiologie
Caloric Restriction
VLAG
In vitro fertilisation
Body Weight
Ovary
0402 animal and dairy science
Maternal Nutritional Physiological Phenomena
Cell Biology
porcine
040201 dairy & animal science
Follicular fluid
Follicular Fluid
in vitro fertilization (IVF)
In vitro maturation
030104 developmental biology
gonadal steroids
Reproductive Medicine
Oocytes
WIAS
Fysiologie van Mens en Dier
Energy Metabolism
metabolism
Zdroj: Biology of Reproduction. Society for the Study of Reproduction
Biology of Reproduction, 102(2), 388-398
Biology of Reproduction
Biology of Reproduction 102 (2020) 2
ISSN: 1529-7268
0006-3363
Popis: Metabolic demands of modern hybrid sows have increased over the years, which increases the chance that sows enter a substantial negative energy balance (NEB) during lactation. This NEB can influence the development of follicles and oocytes that will give rise to the next litter. To study effects of a lactational NEB on follicular development, we used 36 primiparous sows of which 18 were subjected to feed restriction (3.25 kg/day) and 18 were full-fed (6.5 kg/day) during the last 2 weeks of a 24.1 ± 0.3 day lactation. Feed restriction resulted in a 70% larger lactational body weight loss and 76% higher longissimus dorsi depth loss, but similar amounts of backfat loss compared to the full fed sows. These changes were accompanied by lower plasma insulin-like growth factor 1 (IGF1) and higher plasma creatinine levels in the restricted sows from the last week of lactation onward. Ovaries were collected 48 h after weaning. Restricted sows had a lower average size of the 15 largest follicles (−26%) and cumulus–oocyte complexes showed less expansion after 22 h in vitro maturation (−26%). Less zygotes of restricted sows reached the metaphase stage 24 h after in vitro fertilization and showed a higher incidence of polyspermy (+89%). This shows that feed restriction had severe consequences on oocyte developmental competence. Follicular fluid of restricted sows had lower IGF1 (−56%) and steroid levels (e.g., β-estradiol, progestins, and androgens), which indicated that follicles of restricted sows were less competent to produce steroids and growth factors needed for oocytes to obtain full developmental competence.
Summary sentence: Premating feed restriction results in lower oocyte developmental competence, which might be explained by reduced follicular steroid and growth factor production.
Databáze: OpenAIRE
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