Comparison of Efficacy of Teriparatide (Parathyroid Hormone 1-34) Alone and in Combination with Zoledronic Acid for Osteoporosis in Postmenopausal Women
| Autor: | Yuxing Qu, Kang Wei, Yi Gao, Yong Ma |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Osteoporosis Urology Parathyroid hormone Zoledronic Acid N-terminal telopeptide Bone Density Teriparatide medicine Humans Osteopontin Osteoporosis Postmenopausal Femoral neck Bone mineral Lumbar Vertebrae Bone Density Conservation Agents biology business.industry General Medicine medicine.disease Postmenopause medicine.anatomical_structure Zoledronic acid Parathyroid Hormone biology.protein Female business medicine.drug |
| Zdroj: | Journal of the College of Physicians and Surgeons Pakistan. 31:240-242 |
| ISSN: | 1681-7168 1022-386X |
| Popis: | The purpose of this study was to compare the efficacy of teriparatide (parathyroid hormone 1-34) alone and in combination with zoledronic acid (ZA) for the treatment of osteoporosis in postmenopausal women. Ninety-six patients were randomly equally divided into Groups A (n=48) and B (n=48). Group A was given parathyroid hormone 1-34 alone. Group B was treated with parathyroid hormone 1-34 plus ZA. Visual analogue scale (VAS) score, bone mineral density(BMD), serum osteopontin (OPN), and C-terminal cross-linking telopeptide of type I collagen (S-CTX) etc. were compared. After 6 months of treatment, VAS score, serum OPN and S-CTX levels in Group B were significantly lower than those in Group A (p=0.001, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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