Transcranial direct current stimulation applied after encoding facilitates episodic memory consolidation in older adults
| Autor: | Rosa Manenti, Maria Cotelli, Danila Rusich, Gergely Janos Bartl, Elena Gobbi, Marco Sandrini |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Aging Settore M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA Cognitive Neuroscience medicine.medical_treatment Memory Episodic Prefrontal Cortex Experimental and Cognitive Psychology Transcranial Direct Current Stimulation tDCS 050105 experimental psychology 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Double-Blind Method Memory Encoding (memory) medicine Humans 0501 psychology and cognitive sciences Prefrontal cortex Episodic memory Aged Memory Consolidation Memory Disorders Recall Consolidation (soil) Transcranial direct-current stimulation Enhancement 05 social sciences Consolidation Female Memory consolidation Verbal memory Episodic Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurobiology of learning and memory. 163 |
| ISSN: | 1095-9564 |
| Popis: | Episodic memory shows the largest degree of age-related memory decline. There is evidence that consolidation, the process that stabilizes memories after encoding, is reduced in older adults. Previous studies have shown that transcranial direct current stimulation (tDCS) applied during intentional encoding or immediately after a contextual reminder enhanced delayed episodic memory performance, suggesting a potential interaction between tDCS and consolidation or reconsolidation processes. The present randomized, double-blind, sham-controlled study addressed the question whether tDCS applied immediately after verbal encoding enhances episodic memory recall through consolidation in healthy older adults. Twenty-eight participants received tDCS (Active or Sham) over the prefrontal cortex (anode over the left dorsolateral prefrontal cortex and cathode over the contralateral supraorbital region), a brain region contributing to episodic memory function. Verbal recall was tested two days and one month later. The results showed that recall performance at one month was enhanced in the Active tDCS group relative to the Sham group. These findings suggest that tDCS applied off-line immediately after encoding over the prefrontal cortex interacts with the processes promoting consolidation of episodic memories in healthy older adults. Targeting consolidation by means of tDCS might be a novel strategy for reducing episodic memory decline. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect