Growth arrest-specific protein 6 (Gas6) as a noninvasive biomarker for early detection of diabetic nephropathy
Autor: | Jiehui Shan, Wenni Li, Lina Ge, Chunbing Zhang, Junlin Wang, Jianping Liu |
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Rok vydání: | 2017 |
Předmět: |
Male
0301 basic medicine medicine.medical_specialty Physiology Early detection 030204 cardiovascular system & hematology urologic and male genital diseases Gastroenterology Blood Urea Nitrogen Body Mass Index Diabetic nephropathy 03 medical and health sciences 0302 clinical medicine Internal medicine Internal Medicine medicine Albuminuria Humans Diabetic Nephropathies Cystatin C Growth arrest-specific protein 6 Aged Noninvasive biomarkers Glycated Hemoglobin biology Waist-Hip Ratio GAS6 business.industry General Medicine medicine.disease female genital diseases and pregnancy complications Early Diagnosis 030104 developmental biology Endocrinology Diabetes Mellitus Type 2 ROC Curve Case-Control Studies Creatinine Hypertension biology.protein Intercellular Signaling Peptides and Proteins Biomarker (medicine) Female business Biomarkers |
DOI: | 10.6084/m9.figshare.5012369.v1 |
Popis: | Background: To investigate the diagnostic level of cystatin C and growth arrest-specific gene 6 (Gas6) levels in elderly type 2 diabetic patients with different degrees of diabetic nephropathy (DN). Methods: Four hundred and eighty-two old people, including 130 healthy controls, 130 normoalbuminuric diabetic patients, 122 with microalbuminuria, and 100 with macroalbuminuria, were recruited. Plasma Gas6 and serum cystatin C levels were measured. Results: Plasma Gas6 concentration was significantly lower in diabetic patients with microalbuminuria or macroalbuminuria, as compared with diabetic subjects with normoalbuminuria; while cystatin C was significantly higher. Gas6 was inversely correlated with BMI, WHR, and HbA1c, while cystatin C was inversely correlated with urea nitrogen and creatinine. Multivariate logistic regression analysis showed that, after adjusted for established diabetes risk factors, higher plasma Gas6 was significantly associated with a decreased risk of DN, while higher serum cystatin C was significantly associated with an increased risk. Receiver operating characteristic curve analysis showed that Gas6 was better than cystatin C as a biomarker for early diagnosis and detection of DN, with a cutoff value of 9.435 ng/mL (86.1% sensitivity and 84.6% specificity). Conclusion: Compared to cystatin C, Gas6 may be potentially a better noninvasive diagnostic biomarker for early detection of DN. |
Databáze: | OpenAIRE |
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