Growth arrest-specific protein 6 (Gas6) as a noninvasive biomarker for early detection of diabetic nephropathy

Autor: Jiehui Shan, Wenni Li, Lina Ge, Chunbing Zhang, Junlin Wang, Jianping Liu
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
medicine.medical_specialty
Physiology
Early detection
030204 cardiovascular system & hematology
urologic and male genital diseases
Gastroenterology
Blood Urea Nitrogen
Body Mass Index
Diabetic nephropathy
03 medical and health sciences
0302 clinical medicine
Internal medicine
Internal Medicine
medicine
Albuminuria
Humans
Diabetic Nephropathies
Cystatin C
Growth arrest-specific protein 6
Aged
Noninvasive biomarkers
Glycated Hemoglobin
biology
Waist-Hip Ratio
GAS6
business.industry
General Medicine
medicine.disease
female genital diseases and pregnancy complications
Early Diagnosis
030104 developmental biology
Endocrinology
Diabetes Mellitus
Type 2
ROC Curve
Case-Control Studies
Creatinine
Hypertension
biology.protein
Intercellular Signaling Peptides and Proteins
Biomarker (medicine)
Female
business
Biomarkers
DOI: 10.6084/m9.figshare.5012369.v1
Popis: Background: To investigate the diagnostic level of cystatin C and growth arrest-specific gene 6 (Gas6) levels in elderly type 2 diabetic patients with different degrees of diabetic nephropathy (DN). Methods: Four hundred and eighty-two old people, including 130 healthy controls, 130 normoalbuminuric diabetic patients, 122 with microalbuminuria, and 100 with macroalbuminuria, were recruited. Plasma Gas6 and serum cystatin C levels were measured. Results: Plasma Gas6 concentration was significantly lower in diabetic patients with microalbuminuria or macroalbuminuria, as compared with diabetic subjects with normoalbuminuria; while cystatin C was significantly higher. Gas6 was inversely correlated with BMI, WHR, and HbA1c, while cystatin C was inversely correlated with urea nitrogen and creatinine. Multivariate logistic regression analysis showed that, after adjusted for established diabetes risk factors, higher plasma Gas6 was significantly associated with a decreased risk of DN, while higher serum cystatin C was significantly associated with an increased risk. Receiver operating characteristic curve analysis showed that Gas6 was better than cystatin C as a biomarker for early diagnosis and detection of DN, with a cutoff value of 9.435 ng/mL (86.1% sensitivity and 84.6% specificity). Conclusion: Compared to cystatin C, Gas6 may be potentially a better noninvasive diagnostic biomarker for early detection of DN.
Databáze: OpenAIRE
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