Portable High-Flow Nasal Oxygen during Walking in Patients with Severe Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial
| Autor: | Manuela Piran, Barbara Fusar Poli, Piero Ceriana, Nicolino Ambrosino, Alberto Malovini, Giuditta Bettinelli, Annalisa Carlucci, Serena Cirio, Veronica Rossi |
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| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_treatment chemistry.chemical_element Walk Test Walking Oxygen law.invention Exercise training Inspiratory Capacity Pulmonary Disease Chronic Obstructive Randomized controlled trial law Oxygen therapy Exercise capacity Six-minute walking test medicine Humans Venturi mask Dyspnea Oxygen saturation (medicine) COPD Exercise Tolerance medicine.diagnostic_test business.industry medicine.disease Pulse oximetry chemistry Anesthesia Exercise Test business |
| Zdroj: | Respiration. 100:1158-1164 |
| ISSN: | 1423-0356 0025-7931 |
| Popis: | Background: High-flow nasal oxygen (HFNO) improves exercise capacity, oxygen saturation, and symptoms in patients with chronic obstructive pulmonary disease (COPD). Due to the need of electricity supply, HFNO has not been applied during free ambulation. Objective: We evaluated whether HFNO delivered during walking by a battery-supplied portable device was more effective than usual portable oxygen in improving exercise capacity in patients with COPD and severe exercise limitation. The effects on 6-min walking tests (6MWTs) were the primary outcome. Methods: After a baseline 6MWT, 20 stable patients requiring an oxygen inspiratory fraction (FiO2) 2. Walked distance, perceived dyspnea, pulse oximetry, and inspiratory capacity at end of the tests as well as patients’ comfort were compared between the tests. Results: As compared to baseline, walked distance improved significantly more in HFNO than in the control test (by 61.1 ± 37.8 and 39.7 ± 43.8 m, respectively, p = 0.01). There were no significant differences between the tests in dyspnea, peripheral oxygen saturation, or inspiratory capacity, but HFNO test was appreciated as more comfortable. Conclusion: In patients with COPD and severe exercise limitation, HFNO delivered by a battery-supplied portable device was more effective in improving walking distance than usual oxygen supplementation. |
| Databáze: | OpenAIRE |
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