Successful treatment of mycobacterial infection associated hemophagocytic lymphohistiocytosis with etoposide and anti-tuberculous therapy: a case report
| Autor: | Xiao-Wei Shi, Benquan Wu, Yan-Hong Wang, Jun-Hui Ba |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Tuberculosis Pancytopenia Biopsy Antitubercular Agents Case Report Hemophagocytic lymphohistiocytosis Lung biopsy Tuberculosis Etoposide Lymphohistiocytosis Hemophagocytic lcsh:Infectious and parasitic diseases Mycobacterium tuberculosis Immunocompromised Host Mycobacterium infection hemic and lymphatic diseases medicine Humans Topoisomerase II Inhibitors lcsh:RC109-216 Etoposide biology Bone Marrow Smear business.industry fungi medicine.disease biology.organism_classification Dermatology Early Diagnosis Treatment Outcome Infectious Diseases Ferritins Hemophagocytosis business Follow-Up Studies medicine.drug |
| Zdroj: | BMC Infectious Diseases BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-6 (2020) |
| ISSN: | 1471-2334 |
| DOI: | 10.1186/s12879-020-05016-4 |
| Popis: | Background Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially life-threatening disorder characterized by an exacerbated but ineffective inflammatory response, which can be classified as primary and secondary HLH. HLH associated with Mycobacterium tuberculosis is uncommon. This case report accounted an immunocompetent patient who was confirmed to be Mycobacterium infection, or rather, highly suspected tuberculosis (TB) associated HLH, with a favorable outcome. Case presentation A 36-year-old man presented with persistent fever, pancytopenia, and hyperferritinemia. A bone marrow smear demonstrated hemophagocytosis, and pathological examination of lung biopsy was positive for acid-fast bacilli, which established the diagnosis of Mycobacterium infection and HLH. Then the patient treated successfully with anti-TB therapy, along with 8 weeks of etoposide. Conclusion This case emphasizes that HLH should be kept in mind when clinicians encounter a patient with severe infection presenting with pancytopenia and hyperferritinemia. Given the high mortality, early diagnosis and appropriate therapy can provide patients with a favorable prognosis. |
| Databáze: | OpenAIRE |
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