Major Histocompatibility Complex Class I‐Related Chain A Alleles and Histology of Nonalcoholic Fatty Liver Disease
| Autor: | Daisong Tan, Brian Lam, Zachary Goodman, Azza Karrar, Ali Moosvi, Sean Felix, Sohailla Noor, Donna Esmaeili, Lakshmi Alaparthi, Irfan Ali, Dinan Abdelatif, Mohamad Houry, Siddharth Hariharan, Munkhzul Otgonsuren, Zobair M. Younossi, Bijal Rajput |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Lower risk Gastroenterology Pathogenesis Non-alcoholic Fatty Liver Disease Fibrosis Internal medicine Nonalcoholic fatty liver disease medicine Humans Alleles Univariate analysis Polymorphism Genetic Hepatology business.industry Liver cell Histocompatibility Antigens Class I Original Articles Odds ratio Middle Aged medicine.disease stomatognathic diseases Logistic Models Multivariate Analysis Female Original Article Gene polymorphism business |
| Zdroj: | Hepatology Communications |
| ISSN: | 2471-254X |
| DOI: | 10.1002/hep4.1610 |
| Popis: | Major histocompatibility complex class I‐related chain A (MICA) is a highly polymorphic gene that modulates immune surveillance by binding to its receptor on natural killer cells, and its genetic polymorphisms have been associated with chronic immune‐mediated diseases. The progressive form of nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), is characterized by accumulation of fat and inflammatory cells in the hepatic parenchyma, potentially leading to liver cell injury and fibrosis. To date, there are no data describing the potential role of MICA in the pathogenesis of NAFLD. Therefore, our aim was to assess the association between MICA polymorphism and NASH and its histologic features. A total of 134 subjects were included. DNA from patients with biopsy‐proven NAFLD were genotyped using polymerase chain reaction–sequence‐specific oligonucleotide for MICA alleles. Liver biopsies were assessed for histologic diagnosis of NASH and specific pathologic features, including stage of fibrosis and grade of inflammation. Multivariate analysis was performed to draw associations between MICA alleles and the different variables; P ≤ 0.05 was considered significant. Univariate analysis showed that MICA*011 (odds ratio [OR], 7.14; 95% confidence interval [CI], 1.24‐41.0; P = 0.04) was associated with a higher risk for histologic NASH. Multivariate analysis showed that MICA*002 was independently associated with a lower risk for focal hepatocyte necrosis (OR, 0.24; 95% CI, 0.08‐0.74; P = 0.013) and advanced fibrosis (OR, 0.11; 95% CI, 0.02‐0.70; P = 0.019). MICA*017 was independently associated with a higher risk for lymphocyte‐mediated inflammation (OR, 5.12; 95% CI, 1.12‐23.5; P = 0.035). Conclusion: MICA alleles may be associated with NASH and its histologic features of inflammation and fibrosis. Additional research is required to investigate the potential role of MICA in increased risk or protection against NAFLD. |
| Databáze: | OpenAIRE |
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