Lung Clearance of Aerosolized 99mTc Erythromycin Lactobionate in Rabbits
| Autor: | Türkan Ertay, Özlem Kut, Ataman Güre, Serir Aktoğu, Hatice Durak, Hulya Guven, Elvan Sayit |
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| Rok vydání: | 1996 |
| Předmět: |
Cancer Research
Metabolic Clearance Rate Mucociliary clearance Partial Pressure Erythromycin Pharmacology Erythromycin Lactobionate Reference Values Administration Inhalation medicine Animals Radiology Nuclear Medicine and imaging Radionuclide Imaging Lung Aerosolization Aerosols Inhalation business.industry Smoking Pulmonary Surfactants Organotechnetium Compounds Carbon Dioxide Hydrogen-Ion Concentration Oxygen medicine.anatomical_structure Immunology Breathing Molecular Medicine Rabbits Pulmonary alveolus business Half-Life medicine.drug |
| Zdroj: | Nuclear Medicine and Biology. 23:291-293 |
| ISSN: | 0969-8051 |
| DOI: | 10.1016/0969-8051(95)02080-2 |
| Popis: | In order to assess the lung clearance of aerosolized 99m Tc Erythromycin Lactohionate (EL), 99m Tc EL was administered to 9 New Zealand rabbits by inhalation. 5 rabbits inhaled cigarette smoke before 99m Tc EL. Clearance half times were 3.0 ± 0.9 hours in normals, 5.5 ± 1.0 hours after smoke exposure. Clearance was not affected after destroying the surfactant layer. Slower clearance after smoke exposure may be due to the inhibition of mucociliary clearance. 99m Tc EL can be considered as an alternative radioaerosol for ventilation imaging. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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