Histone H3.3 Mutations: A Variant Path to Cancer
| Autor: | Paul S. Knoepfler, Benjamin T. K. Yuen |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Pediatric Research Initiative
Cancer Research Epigenetic regulation of neurogenesis Carcinogenesis Pediatric Cancer Oncology and Carcinogenesis Mutation Missense Biology Article Epigenesis Genetic Histones Histone H3 Rare Diseases Genetic Genetics Animals Humans 2.1 Biological and endogenous factors Oncology & Carcinogenesis Cancer epigenetics Aetiology Cancer Epigenomics Pediatric Neoplastic Histone deacetylase 5 HDAC11 HDAC10 Human Genome Neurosciences Glioma Cell Biology HDAC4 Cell biology Gene Expression Regulation Neoplastic Gene Expression Regulation Oncology Mutation Missense Epigenesis |
| Zdroj: | Cancer cell, vol 24, iss 5 |
| ISSN: | 1535-6108 |
| DOI: | 10.1016/j.ccr.2013.09.015 |
| Popis: | A host of cancer types exhibit aberrant histone modifications. Recently, distinct and recurrent mutations in a specific histone variant, histone H3.3, have been implicated in a high proportion of malignant pediatric brain cancers. The presence of mutant H3.3 histone disrupts epigenetic post-translational modifications near genes involved in cancer processes and in brain function. Here, we propose several possible mechanisms by which mutant H3.3 histones may act to promote tumorigenesis. Furthermore, we discuss how perturbations in normal H3.3 chromatin-related and epigenetic functions may more broadly contribute to the formation of human cancers. |
| Databáze: | OpenAIRE |
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