Skin Response to Delayed Hypersensitivity Testing in Persons With Unilateral Stroke-related Paresis: Implications for People With Spinal Cord Injury
| Autor: | Barbara W. Trautner, Kuno P. Zimmermann, Sara A. Squyres, Rabih O. Darouiche |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Tuberculin Functional Laterality Internal medicine medicine Humans Hypersensitivity Delayed Prospective Studies Prospective cohort study Stroke Veterans Affairs Spinal cord injury Aged Skin Tests Veterans Paresis Immunity Cellular Rehabilitation business.industry Original Contribution Middle Aged medicine.disease Cross-Sectional Studies Delayed hypersensitivity Physical therapy Neurology (clinical) medicine.symptom business |
| Zdroj: | The Journal of Spinal Cord Medicine. 30:362-365 |
| ISSN: | 2045-7723 1079-0268 |
| Popis: | BACKGROUND Vaccination rates among individuals with spinal cord injury (SCI) could be improved if it can be shown that vaccination performed on insensate areas is effective. This would eliminate the the risk of discomfort and soreness at the injection site. OBJECTIVE To determine whether immune responsiveness varies between areas with intact and impaired innervation in patients with stroke-related paresis. DESIGN Prospective trial in which each subject served as his or her own control. SETTING Rehabilitation wards and long-term care units at a Veterans Affairs Medical Center. PATIENTS Individuals with a history of cerebrovascular accident (CVA) affecting 1 side of the body. METHODS The Multitest cell-mediated immunity (CMI) and purified protein derivative (PPD) of tuberculin were administered intradermally to each arm of each subject. MAIN OUTCOME MEASURES Total millimeters of induration in response to either test and positive vs negative responses to either test were compared between the 2 arms of each subject. RESULTS Response to delayed hypersensitivity testing did not differ between the arms affected and unaffected by CVA in each subject, and the time since CVA also did not affect the magnitude of the skin response. CONCLUSIONS Skin testing for delayed hypersensitivity can be effectively administered in the paretic arms of persons who have experienced CVA. Although this study was performed in patients with stroke-related impairment, it has implications for vaccine administration in individuals with SCI-related neurologic deficits. |
| Databáze: | OpenAIRE |
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