Use of Dopamine Agonist in Tetanus Spasms - A Novel Approach to Revert the Respiratory Spasm - The Cause of Mortality
| Autor: | Lori Tewari, Abhishek Gupta, Devesh Johari, Vinod Kumar Tewari |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Economics and Econometrics
Levodopa Synaptic cleft Tetanus business.industry Central nervous system Motor nerve Forestry Pharmacology medicine.disease Inhibitory postsynaptic potential Dopamine agonist medicine.anatomical_structure Carbidopa Materials Chemistry Media Technology medicine business medicine.drug |
| Zdroj: | Acta Scientific Neurology. 3:30-32 |
| ISSN: | 2582-1121 |
| DOI: | 10.31080/asne.2020.03.0226 |
| Popis: | In tetanus patients Levodopa and Carbidopa combination (which is usually used to relieve the signs of extrapyramidal) causes respiratory muscles spasm relief thereby the need for sedatives is decreased and patient saved later on via central nervous system mechanism, by providing the inhibitory neurotransmitters at Anterior Horn cells. The tetanus toxin initially binds to peripheral nerve terminals then it retrogradely goes to CNS attaches with gangliosides at presynaptic inhibitory motor nerve endings, blocks glycine and gamma amino butyric acid (GABA) across the synaptic cleft. |
| Databáze: | OpenAIRE |
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