Neural and Behavioral Correlates of Alcohol-Induced Aggression Under Provocation
| Autor: | Michael N. Smolka, Michael Marxen, Ulrich S. Zimmermann, Gabriela Gan, Philipp Sterzer |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Poison control Context (language use) Neuropsychological Tests Amygdala Young Adult Alcohol intoxication Internal medicine Reaction Time medicine Humans Psychiatry Prefrontal cortex Anterior cingulate cortex Pharmacology Brain Mapping Cross-Over Studies Ethanol Aggression Ventral striatum Brain Central Nervous System Depressants medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health medicine.anatomical_structure Endocrinology Original Article Female medicine.symptom Psychology Alcoholic Intoxication |
| Zdroj: | Neuropsychopharmacology. 40:2886-2896 |
| ISSN: | 1740-634X 0893-133X |
| Popis: | Although alcohol consumption is linked to increased aggression, its neural correlates have not directly been studied in humans so far. Based on a comprehensive neurobiological model of alcohol-induced aggression, we hypothesized that alcohol-induced aggression would go along with increased amygdala and ventral striatum reactivity and impaired functioning of the prefrontal cortex (PFC) under alcohol. We measured neural and behavioral correlates of alcohol-induced aggression in a provoking vs non-provoking condition with a variant of the Taylor aggression paradigm (TAP) allowing to differentiate between reactive (provoked) and proactive (unprovoked) aggression. In a placebo-controlled cross-over design with moderate alcohol intoxication (~0.6 g/kg), 35 young healthy adults performed the TAP during functional magnetic resonance imaging (fMRI). Analyses revealed that provoking vs non-provoking conditions and alcohol vs placebo increased aggression and decreased brain responses in the anterior cingulate cortex/dorso-medial PFC (provoking |
| Databáze: | OpenAIRE |
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