| Autor: |
N. Saraco, Marcos Palligas, Alicia Belgorosky, María Sonia Baquedano, Claudia Cannizzaro, Cristina Nemer |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Journal of the Endocrine Society |
| ISSN: |
2472-1972 |
| Popis: |
Estrogens play important role in the placenta throughout the gestation. Human placenta (PL) expresses high levels of ERRγ type 1 isoform as well as Aromatase (Aro).ERRγ1has also be described as possibly implicated in the regulation of theenergy metabolism in PL, however its physiological role is not yet clear.Aro is the key enzyme for estrogen biosynthesis from androgens and in human placenta is expressed exclusively in syncytiotrophoblast. It has been described that ERRγ serves as an oxygen-responsive transcription factor that regulates Aro gene expression in PL.We have previously described splicing variants of AromRNA(1-2). Our aim was to analyze ERRγ1 mRNA expression and Aro mRNA active variant expression in PL from term LGA and preterm (PT) ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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