Small intestinal disease in T cell deficiency
| Autor: | Ward A. Olsen, Ralph M. Albrecht, Sheldon D. Horowitz, Vilja Lorenzsonn, Richard Hong |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Diarrhea
Male Pathology medicine.medical_specialty Malabsorption Biopsy T-Lymphocytes T cell Disease Chronic granulomatous disease Malabsorption Syndromes Immunity Intestine Small Humans Medicine B-Lymphocytes Immunity Cellular Lamina propria business.industry Macrophages Immunologic Deficiency Syndromes Infant medicine.disease T cell deficiency Epithelium Intestinal Diseases Microscopy Electron medicine.anatomical_structure Child Preschool Pediatrics Perinatology and Child Health Immunology Female business |
| Zdroj: | The Journal of Pediatrics. 85:457-462 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/s0022-3476(74)80444-0 |
| Popis: | Biopsies of the proximal small bowel were obtained in four children with impairment of cell-mediated immunity, chronic diarrhia, and malabsorption; one child had an isolated T cell defect and three had significant B and T cell defects. All of them had malabsorption and, in addition to alterations of the small bowel epithelium, large vacuolated macrophages were seen in the lamina propria in all biopsies. Electron microscopy demonstrated lipid and patches of small pleomorphic inclusions within the macrophages. Since large vacuolated macrophages have also been described in Whipple's disease and chronic granulomatous disease, we suggest the possibility of a common thread of defective host defense and gastrointestinal malfunction in these three conditions. |
| Databáze: | OpenAIRE |
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