Seizures After Pediatric Vilazodone Ingestion: A Case Series
| Autor: | Elon K. Fernandez, Kathryn T. Kopec, Erin M. Noyes, Jesse Wenger, Matthew Salzman, Fred M. Henretig, Jeannine Del Pizzo |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Serotonin reuptake inhibitor Vilazodone Hydrochloride Status epilepticus Partial agonist 03 medical and health sciences chemistry.chemical_compound Benzodiazepines 0302 clinical medicine Seizures Vilazodone medicine Ingestion Humans business.industry 030208 emergency & critical care medicine General Medicine medicine.disease chemistry Child Preschool Pediatrics Perinatology and Child Health Toxicity Emergency Medicine Major depressive disorder medicine.symptom business Emergency Service Hospital 030217 neurology & neurosurgery Selective Serotonin Reuptake Inhibitors |
| Zdroj: | Pediatric emergency care. 34(3) |
| ISSN: | 1535-1815 |
| Popis: | Vilazodone hydrochloride is the first member in a new class of antidepressants called indolealkylamines and was approved for use in the United States in 2011 for major depressive disorder. It has a combined mechanism of action of a selective serotonin reuptake inhibitor and a partial agonist of serotonin 5-HT1A receptors. It has not been approved for use in the pediatric population, and toxicity from exploratory vilazodone ingestion has been rarely described to date. We describe 2 children with laboratory-confirmed vilazodone ingestions that led to significant toxicity including refractory status epilepticus in 1 patient and likely transient seizure activity in the other. Both patients required multiple doses of benzodiazepines; in the more severe case, barbiturates were added to control seizure activity. These children returned to baseline and had no prolonged neurologic complications. Pediatric experience with vilazodone is limited; however, the literature demonstrates 3 additional case reports of children experiencing seizure after vilazodone ingestion. With the 2 new cases presented here, it seems prudent to educate prescribers and families of the potential dangers of ingestion of vilazodone tablets by young children. |
| Databáze: | OpenAIRE |
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