Decreased circulating dipeptidyl peptidase-4 enzyme activity is prognostic for severe outcomes in COVID-19 inpatients
| Autor: | Ákos Nádasdi, György Sinkovits, Ilona Bobek, Botond Lakatos, Zsolt Förhécz, Zita Z Prohászka, Marienn Réti, Miklós Arató, Gellért Cseh, Tamás Masszi, Béla Merkely, Péter Ferdinandy, István Vályi-Nagy, Zoltán Prohászka, Gábor Firneisz |
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| Rok vydání: | 2022 |
| Předmět: |
Adult
Male Inpatients Interleukin-6 SARS-CoV-2 Dipeptidyl Peptidase 4 Biochemistry (medical) Clinical Biochemistry COVID-19 Middle Aged Prognosis Severity of Illness Index C-Reactive Protein Logistic Models ROC Curve Multivariate Analysis Drug Discovery Humans Female Biomarkers Aged Retrospective Studies |
| Zdroj: | Biomarkers in Medicine. 16:317-330 |
| ISSN: | 1752-0371 1752-0363 |
| DOI: | 10.2217/bmm-2021-0717 |
| Popis: | Aim: To investigate the serum circulating DPP4 activity in patients with COVID-19 disease. Materials & methods: Serum samples from 102 hospitalized COVID-19 patients and 43 post-COVID-19 plasma donors and 39 SARS-CoV-2 naive controls and their medical data were used. Circulating DPP4 activities according to different COVID-19 disease peak severity (WHO) groups at sampling and at peak were assessed. Results: A significant decrease (p [area = 0.5] < 0.0001) as single predictor and 83.45% (p[area = 0.5] < 0.0001) in combination with age among hospitalized patients with COVID-19. Conclusion: Decreased circulating DPP4 activity is associated with severe COVID-19 disease and is a strong prognostic biomarker of mortality. |
| Databáze: | OpenAIRE |
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