Proteomics in human Parkinson's disease research
| Autor: | Pierre R. Burkhard, Eniko Veronika Kovari, Denis F. Hochstrasser, Virginie Licker |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Proteomics
Parkinson's disease Biomedical Research Proteome Biophysics Substantia nigra Disease Biochemistry Protein Processing Post-Translational/physiology Proteomics/methods chemistry.chemical_compound Biomedical Research/trends Nerve Degeneration/etiology/metabolism medicine Proteome/analysis Humans ddc:576 Alpha-synuclein Lewy body business.industry Mechanism (biology) Neurodegeneration Brain Parkinson Disease medicine.disease ddc:616.8 chemistry Brain/metabolism/pathology Nerve Degeneration Disease Progression Lewy Bodies Parkinson Disease/cerebrospinal fluid/etiology/*metabolism/pathology business Lewy Bodies/metabolism/pathology Neuroscience Protein Processing Post-Translational |
| Zdroj: | Journal of Proteomics, Vol. 73, No 1 (2009) pp. 10-29 |
| ISSN: | 1876-7737 1874-3919 |
| Popis: | During the last decades, considerable advances in the understanding of specific mechanisms underlying neurodegeneration in Parkinson's disease have been achieved, yet neither definite etiology nor unifying sequence of molecular events has been formally established. Current unmet needs in Parkinson's disease research include exploring new hypotheses regarding disease susceptibility, occurrence and progression, identifying reliable diagnostic, prognostic and therapeutic biomarkers, and translating basic research into appropriate disease-modifying strategies. The most popular view proposes that Parkinson's disease results from the complex interplay between genetic and environmental factors and mechanisms believed to be at work include oxidative stress, mitochondrial dysfunction, excitotoxicity, iron deposition and inflammation. More recently, a plethora of data has accumulated pinpointing an abnormal processing of the neuronal protein alpha-synuclein as a pivotal mechanism leading to aggregation, inclusions formation and degeneration. This protein-oriented scenario logically opens the door to the application of proteomic strategies to this field of research. We here review the current literature on proteomics applied to Parkinson's disease research, with particular emphasis on pathogenesis of sporadic Parkinson's disease in humans. We propose the view that Parkinson's disease may be an acquired or genetically-determined brain proteinopathy involving an abnormal processing of several, rather than individual neuronal proteins, and discuss some pre-analytical and analytical developments in proteomics that may help in verifying this concept. |
| Databáze: | OpenAIRE |
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