Histoenzymological Characteristics of the Contractile Myocardium in Experimental Stenosis of the Aorta
| Autor: | M. S. Tverskaya, M. Kh. Kadyrova, V. V. Karpova, V. V. Sukhoparova, V. Yu. Klyuchikov |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Heart Ventricles Citric Acid Cycle Guinea Pigs Glycerolphosphate Dehydrogenase Ventricular Septum General Biochemistry Genetics and Molecular Biology Hydroxybutyrate Dehydrogenase Glycolysis Inhibition Afterload Malate Dehydrogenase Internal medicine medicine.artery medicine Animals Glycolysis Dihydrolipoamide Dehydrogenase Heart Failure Aorta L-Lactate Dehydrogenase Chemistry Myocardium NADPH Dehydrogenase Aortic Valve Stenosis General Medicine Metabolism medicine.disease Myocardial Contraction Isocitrate Dehydrogenase Succinate Dehydrogenase Citric acid cycle Stenosis Heart failure Cardiology |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 152:108-111 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-011-1467-9 |
| Popis: | Contractile cardiomyocyte metabolism was studied by histochemical methods in experimental stenosis of the aorta complicated and not by heart failure. Acceleration of the citric acid cycle, more intense oxidation of free fatty acids and their metabolites, glycolysis intensification, and higher activity of shuttle mechanisms were found in the contractile cardiomyocytes in stenosis of the aorta not complicated by heart failure. The presence of these metabolic shifts in the myocardium of all studied compartments suggests their association with not only more intense heart work, but also with the effects of total systems neurohumoral factors. Comparative study of myocardial metabolism in two variants of experimental stenosis of the aorta has revealed changes prognostically unfavorable for the development of heart failure. These changes include exhaustion of glycogen reserve, glycolysis inhibition, and metabolism shift towards biosynthetic processes. These data indicate an important role of glycolysis in support of myocardial contractile function during the acute phase of pressure overloading of the heart. |
| Databáze: | OpenAIRE |
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