Rapid antigen testing as a reactive response to surges in nosocomial SARS-CoV-2 outbreak risk

Autor: Laura Temime, Lulla Opatowski, Jean-Ralph Zahar, David R M Smith, Audrey Duval
Přispěvatelé: Modelling, EMAE-MESuRS Working Group on Nosocomial SARS-CoV-2, Epidémiologie et modélisation de la résistance aux antimicrobiens - Epidemiology and modelling of bacterial escape to antimicrobials (EMAE), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Laboratoire Modélisation, épidémiologie et surveillance des risques sanitaires (MESuRS), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris Cité (UPCité), Imperial College London, The work was supported directly by internal resources from the French National Institute for Health and Medical Research (Inserm), the Institut Pasteur, the Conservatoire National des Arts et Métiers, and the University of Versailles–Saint-Quentin-en-Yvelines/University of Paris-Saclay. This study received funding from the French Government’s 'Investissement d’Avenir' program, Laboratoire d’Excellence 'Integrative Biology of Emerging Infectious Diseases' (Grant ANR-10-LABX-62- IBEID), the MODCOV project from the Fondation de France (Grant 106059) as part of the alliance framework 'Tous unis contre le virus', the Université Paris-Saclay (AAP Covid-19 2020) and the French government through its National Research Agency project SPHINX-17-CE36-0008-01. DS is also supported by a Canadian Institutes of Health Research Doctoral Foreign Study Award (Funding Reference Number 164263)., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-17-CE36-0008,SPHINx,Diffusion de pathogènes au sein des réseaux de soins : une étude de modélisation(2017), Bertram, Marie-Liesse, Integrative Biology of Emerging Infectious Diseases - - IBEID2010 - ANR-10-LABX-0062 - LABX - VALID, Diffusion de pathogènes au sein des réseaux de soins : une étude de modélisation - - SPHINx2017 - ANR-17-CE36-0008 - AAPG2017 - VALID
Rok vydání: 2022
Předmět:
Cost-Benefit Analysis
Psychological intervention
General Physics and Astronomy
law.invention
Disease Outbreaks
law
MESH: Risk Factors
Risk Factors
Health care
MESH: COVID-19
Computational models
MESH: Disease Outbreaks
Antigens
Viral
Cross Infection
Multidisciplinary
Incidence (epidemiology)
Vaccination
MESH: Hospitals
Hospitals
Transmission (mechanics)
Scale (social sciences)
Epidemiological Monitoring
MESH: Antigens
Viral
medicine.medical_specialty
Science
MESH: COVID-19 Serological Testing
Article
General Biochemistry
Genetics and Molecular Biology
COVID-19 Serological Testing
Population screening
medicine
Humans
MESH: SARS-CoV-2
MESH: Diagnostic Tests
Routine
MESH: Humans
business.industry
Diagnostic Tests
Routine
SARS-CoV-2
Public health
Outbreak
MESH: Cross Infection
COVID-19
MESH: Vaccination
General Chemistry
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Viral infection
Emergency medicine
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
MESH: Epidemiological Monitoring
business
MESH: Cost-Benefit Analysis
Zdroj: Nature Communications
Nature Communications, 2022, 13 (1), pp.236. ⟨10.1038/s41467-021-27845-w⟩
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
ISSN: 2041-1723
DOI: 10.1038/s41467-021-27845-w
Popis: Healthcare facilities are vulnerable to SARS-CoV-2 introductions and subsequent nosocomial outbreaks. Antigen rapid diagnostic testing (Ag-RDT) is widely used for population screening, but its health and economic benefits as a reactive response to local surges in outbreak risk are unclear. We simulate SARS-CoV-2 transmission in a long-term care hospital with varying COVID-19 containment measures in place (social distancing, face masks, vaccination). Across scenarios, nosocomial incidence is reduced by up to 40-47% (range of means) with routine symptomatic RT-PCR testing, 59-63% with the addition of a timely round of Ag-RDT screening, and 69-75% with well-timed two-round screening. For the latter, a delay of 4-5 days between the two screening rounds is optimal for transmission prevention. Screening efficacy varies depending on test sensitivity, test type, subpopulations targeted, and community incidence. Efficiency, however, varies primarily depending on underlying outbreak risk, with health-economic benefits scaling by orders of magnitude depending on the COVID-19 containment measures in place.
Healthcare facilities are vulnerable to SARS-CoV-2 introductions and subsequent nosocomial outbreaks. Here, the authors simulate transmission in a long-term care facility with varying containment measures in place and evaluate reactive response with antigen rapid diagnostic testing.
Databáze: OpenAIRE
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