Analysis of Mechanisms of Interaction between Ciprofloxacin-Based Radiopharmaceutical Labeled with Technetium-99m and Cultured Staphylococcus aureus
| Autor: | Yu. N. Il’yushenkova, M. R. Karpova, Natalia Valerievna Varlamova, Yu. B. Lishmanov, S. I. Sazonova |
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| Rok vydání: | 2014 |
| Předmět: |
Staphylococcus aureus
Microbiological culture medicine.drug_class Chemistry Antibiotics Organotechnetium Compounds General Medicine Drug resistance medicine.disease_cause General Biochemistry Genetics and Molecular Biology Anti-Bacterial Agents Microbiology Bacterial genetics Ciprofloxacin Disk Diffusion Antimicrobial Tests Drug Resistance Bacterial medicine Radiopharmaceuticals Antibacterial activity Technetium-99m medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 157:732-734 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-014-2654-2 |
| Popis: | Mechanisms of interaction between ciprofloxacin-based radiopharmaceutical labeled with technetium-99m and cultured Staphylococcus aureus were studied. The substance, reagent for radiopharmaceutical, and the radiopharmaceutical demonstrated similar bactericidal activity against the test bacterial cultures, which confi rmed specifi c antibacterial activity of technetium-99m-labeled ciprofloxacin. The technetium-99m-labeled antibiotic reversibly interacts with inactivated Staphylococcus aureus culture, which indicates the existence of an additional non-specific pathway for radiopharmaceutical accumulation in the bacterial inflammation focus. Our experiment ruled out the possibility of binding free technetium-99m at concentrations |
| Databáze: | OpenAIRE |
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