Extramedullary (skin) presentation of acute monocytic leukemia resembling cutaneous lymphoma: morphological and immunulogical features
| Autor: | M. Palutke, J.C. Blaustein, C. Karanes, S. Narang |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Pathology
medicine.medical_specialty Skin Neoplasms Histology Lymphoma Dermatology Cutaneous lymphoma Pathology and Forensic Medicine Diagnosis Differential Immunoenzyme Techniques medicine Humans T-cell lymphoma Acute monocytic leukemia integumentary system medicine.diagnostic_test business.industry Bone Marrow Examination Middle Aged medicine.disease medicine.anatomical_structure Leukemia Monocytic Acute Monoclonal Skin biopsy Monocytic leukemia Female Bone marrow business |
| Zdroj: | Journal of Cutaneous Pathology. 14:232-237 |
| ISSN: | 1600-0560 0303-6987 |
| DOI: | 10.1111/j.1600-0560.1987.tb01339.x |
| Popis: | Acute monocytic leukemia has been noted to exhibit a predilection for extramedullary involvement (gums, skin, and lymph nodes) at presentation. More unusual is the occurrence in an extramedullary site in the absence of bone marrow involvement. A case is reported with initial presentation in skin preceding a subsequent evolution to a leukemic phase by one year. The skin tumor was initially diagnosed and treated as a lymphoma. A second skin tumor, biopsied one year later was immunophenotyped as a T cell lymphoma using a screening panel of antisera (OKT4 positive, OKMI negative). Shortly thereafter a monocytic leukemia (M5) was discovered. Using a larger panel of antisera and enzyme markers on the second skin biopsy confirmed the monocytic rather than lymphocytic nature of the skin tumor. This case illustrates the importance of using an expanded panel of monoclonal antisera in certain hematopoietic tumors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text