Magnetization transfer measurements of the hippocampus in the early diagnosis of Alzheimer's disease
| Autor: | Haruo Hanyu, Tetsuichi Asano, Hiroaki Shindo, Hirofumi Sakurai, Masaru Takasaki, Kimihiko Abe |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Pathology Clinical Dementia Rating Hippocampus chemical and pharmacologic phenomena Gastroenterology Temporal lobe Central nervous system disease Degenerative disease Atrophy Alzheimer Disease Reference Values Internal medicine mental disorders medicine Humans Single-Blind Method Magnetization transfer Aged medicine.disease Magnetic Resonance Imaging Temporal Lobe Neurology Female Neurology (clinical) Alzheimer's disease Psychology |
| Zdroj: | Journal of the Neurological Sciences. 188:79-84 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/s0022-510x(01)00553-6 |
| Popis: | We measured magnetization transfer ratios (MTRs) of the hippocampus in 38 patients with Alzheimer's disease (AD), including very mild (Clinical Dementia Rating [CDR] 0.5, n=12), mild (CDR 1, n=14), and moderate stages (CDR 2, n=12), and in 21 healthy elderly control subjects. Medial temporal lobe atrophy was graded subjectively on a five-point scale by two observers blinded to clinical data. Compared with the controls, each of the AD groups, including the very mild group, had significant atrophy of the medial temporal lobe and a decrease in MTRs of the hippocampus. Logistic regression analysis revealed that the overall discrimination rate with MTR measurement and visual analysis of the atrophy was 85% and 73% between the control group and the CDR 0.5 group, 89% and 80% between the control group and the CDR 1 group, and 100% and 91% between the control group and the CDR 2 group, respectively. MTR measurements may provide additional information in detecting structural damage of the hippocampus of AD and be helpful in providing improved diagnosis and early detection of AD. |
| Databáze: | OpenAIRE |
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