Complete Genome Sequences, before and after Mammalian Cell Culture, of Zika Virus Isolated from the Serum of a Symptomatic Male Patient from Oaxaca, Mexico
| Autor: | Martha Yocupicio-Monroy, Gustavo Reyes-Terán, Celia Boukadida, Rosalia Lira, Elvira Piten-Isidro, Liliane Martínez-Vargas, Sofia L. Alcaraz-Estrada, Jesus Torres-Flores, Yara A. Luna-Villalobos, Amaranta Rivero-Arrieta, Klintsy J. Torres, Edgar E. Sevilla-Reyes |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
040301 veterinary sciences viruses Single-nucleotide polymorphism 04 agricultural and veterinary sciences Biology biology.organism_classification Virology Genome Zika virus 0403 veterinary science 03 medical and health sciences Flavivirus 030104 developmental biology Cell culture Male patient Viruses Genetics Vero cell Cell isolation Molecular Biology |
| Zdroj: | Genome Announcements |
| ISSN: | 2169-8287 |
| DOI: | 10.1128/genomea.00072-17 |
| Popis: | Zika virus (ZIKV) is an emerging arthropod-borne flavivirus associated with severe congenital malformations and neurological complications. Although the ZIKV genome is well characterized, there is limited information regarding changes after cell isolation and culture adaptation. We isolated, and passaged in Vero cells, ZIKV from the serum of a symptomatic male patient and compared the viral genomes before and after culture. Single nucleotide polymorphisms were characteristic among serum-circulating genomes, while such diversity decreased after cell culture. |
| Databáze: | OpenAIRE |
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