Tranexamic acid versus aminocapróic acid in multiple doses via the oral route for the reduction of postoperative bleeding in total primary hip arthroplasty: a prospective, randomized, double-blind, controlled study
| Autor: | Héctor Noé G. Silva-Ramos, Jesús A García-Pedro, Michelle Morcos-Sandino, Félix Vilchez-Cavazos, Carlos Acosta-Olivo, Tomas Ramos-Morales, Rodolfo Morales-Avalos, Víctor M. Peña-Martínez, Ana María Espinoza-Galindo, Raymundo A. Rodríguez-Torres |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Visual analogue scale Arthroplasty Replacement Hip medicine.medical_treatment Administration Oral Postoperative Hemorrhage 030204 cardiovascular system & hematology Hematocrit law.invention 03 medical and health sciences 0302 clinical medicine Double-Blind Method Randomized controlled trial law medicine Humans Prospective Studies Prospective cohort study Adverse effect Aged medicine.diagnostic_test business.industry Hematology General Medicine Middle Aged Arthroplasty Antifibrinolytic Agents Treatment Outcome Tranexamic Acid Anesthesia Aminocaproic Acid Female Aminocaproic acid business Tranexamic acid 030215 immunology medicine.drug |
| Zdroj: | Blood Coagulation & Fibrinolysis. 32:132-139 |
| ISSN: | 1473-5733 0957-5235 |
| DOI: | 10.1097/mbc.0000000000001005 |
| Popis: | To compare the effects of oral e-aminocaproic acid (EACA) as a hemostatic agent versus the use of oral tranexamic acid (TXA) administered in multiple doses pre and postsurgery in patients undergoing elective primary total hip arthroplasty (THA). We enrolled 102 patients that were randomly divided into two groups: received three oral doses of EACA (2000 mg per dose) or three oral doses of TXA (1300 mg per dose). The medication was given according to the following schedule: 2 h before surgery and 6 and 12 h after surgery. The variables analyzed to compare the effectiveness of the hemostatic agents were total blood loss, hidden blood loss, external blood loss, transfusion rate, intraoperative blood loss, decreases in hemoglobin and hematocrit values, surgical drainage output, visual analog scale, and surgical complications. There were no significant differences between any of the study variables for the group receiving oral TXA and the group receiving oral EACA (P > 0.05). Our study showed that the use of oral EACA was similar to its counterpart TXA regarding the evaluated parameters. TXA did not have superior blood conservation effects, safety profile, or differences in functional scales compared with EACA in THA. We consider the use of multiple oral doses of aminocaproic acid at the selected dose to be effective as a standard protocol to achieve less blood loss and a lower rate of transfusion and adverse events related to the medication in patients undergoing a THA. |
| Databáze: | OpenAIRE |
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