Multimodal Nanomedicine Strategies for Targeting Cancer Cells as well as Cancer Stem Cell Signalling Mechanisms
| Autor: | Rupinder K. Kanwar, Jagat R. Kanwar, Sishir K Kamalapuram, Rasika M Samarasinghe |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Population Antineoplastic Agents Disease Pharmacology 03 medical and health sciences Breast cancer Cancer stem cell Neoplasms Drug Discovery Animals Humans Medicine education education.field_of_study business.industry Cancer General Medicine medicine.disease Nanomedicine 030104 developmental biology Cancer cell Neoplastic Stem Cells Cancer research Stem cell business Signal Transduction |
| Zdroj: | Mini-Reviews in Medicinal Chemistry. 17 |
| ISSN: | 1389-5575 |
| DOI: | 10.2174/1389557516666160219121634 |
| Popis: | Increasing evidence suggests that stem cells, a small population of cells with unique selfrenewable and tumour regenerative capacity, are aiding tumour re-growth and multidrug resistance. Conventional therapies are highly ineffective at eliminating these cells leading to relapse of disease and formation of chemoresistance tumours. Cancer and stem cells targeted therapies that utilizes nanotherapeutics to delivery anti-cancer drugs to specific sites are continuously investigated. This review focuses on recent research using nanomedicine and targeting entities to eliminate cancer cells and cancer stem cells. Current nanotherapeutics in clinical trials along with more recent publications on targeted therapies are addressed. |
| Databáze: | OpenAIRE |
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