Could physical exercises modulate Nrf2–Keap1 pathway in chronic kidney disease?
| Autor: | Denise Mafra, C.C. Abreu, L.F.M.F. Cardozo |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
NF-E2-Related Factor 2 Inflammation Physical exercise Detoxification enzymes Bioinformatics medicine.disease_cause Models Biological Nrf2 pathway Internal medicine medicine Humans Renal Insufficiency Chronic Transcription factor Exercise Medicine(all) Kelch-Like ECH-Associated Protein 1 business.industry Intracellular Signaling Peptides and Proteins General Medicine medicine.disease KEAP1 Oxidative Stress Endocrinology medicine.symptom business Oxidative stress Kidney disease Signal Transduction |
| Zdroj: | Medical Hypotheses. 84(1):44-46 |
| ISSN: | 0306-9877 |
| DOI: | 10.1016/j.mehy.2014.11.013 |
| Popis: | Patients with chronic kidney disease (CKD) have various metabolic disorders caused by a chronic state of oxidative stress and inflammation, and recently, nuclear factor-erythroid 2-related factor 2 (Nrf2) has emerged as a factor that plays a significant role in cellular protection against oxidative stress and inflammation. This transcription factor when activated can regulate antioxidant and anti-inflammatory cellular responses leading to the expression of detoxifying enzymes. Studies have shown that Nrf2 expression can be modulated by several factors, such as bioactive compounds and physical exercise. In fact, exercise in CKD patients can bring many benefits; however, there are no studies correlating physical activity and Nrf2 expression in CKD patients. This review aims to discuss whether there is any evidence to justify a recommendation of physical exercise in CKD patients as a non-pharmacological option to activate the Nrf2 pathway. |
| Databáze: | OpenAIRE |
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